Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase
AbstractBaicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA,while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor tomonophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity andwas a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, weconclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agentswith inhibitory effects in addition to their antioxidant properties.
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Gao, H.; Nishida, J.; Saito, S.; Kawabata, J. Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase. Molecules 2007, 12, 86-97.
Gao H, Nishida J, Saito S, Kawabata J. Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase. Molecules. 2007; 12(1):86-97.Chicago/Turabian Style
Gao, Hong; Nishida, Jun; Saito, Shizuka; Kawabata, Jun. 2007. "Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase." Molecules 12, no. 1: 86-97.