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Molecules 2007, 12(1), 86-97; doi:10.3390/12010086
Article

Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase

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Received: 8 December 2006 / Revised: 24 January 2007 / Accepted: 24 January 2007 / Published: 29 January 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA,while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor tomonophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity andwas a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, weconclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agentswith inhibitory effects in addition to their antioxidant properties.
Keywords: Tyrosinase inhibitor; flavonoids; 5;6;7-trihydroxyflavones; baicalein; melanin; depigmentation. Tyrosinase inhibitor; flavonoids; 5; 6; 7-trihydroxyflavones; baicalein; melanin; depigmentation.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gao, H.; Nishida, J.; Saito, S.; Kawabata, J. Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase. Molecules 2007, 12, 86-97.

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