Molecules 2007, 12(1), 86-97; doi:10.3390/12010086
Article

Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase

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Received: 8 December 2006; in revised form: 24 January 2007 / Accepted: 24 January 2007 / Published: 29 January 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA,while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor tomonophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity andwas a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, weconclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agentswith inhibitory effects in addition to their antioxidant properties.
Keywords: Tyrosinase inhibitor; flavonoids; 5;6;7-trihydroxyflavones; baicalein; melanin; depigmentation.
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MDPI and ACS Style

Gao, H.; Nishida, J.; Saito, S.; Kawabata, J. Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase. Molecules 2007, 12, 86-97.

AMA Style

Gao H, Nishida J, Saito S, Kawabata J. Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase. Molecules. 2007; 12(1):86-97.

Chicago/Turabian Style

Gao, Hong; Nishida, Jun; Saito, Shizuka; Kawabata, Jun. 2007. "Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase." Molecules 12, no. 1: 86-97.

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