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• Nishida, J
• Saito, S
• Kawabata, J
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• Nishida, J
• Saito, S
• Kawabata, J
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• Nishida, J
• Saito, S
• Kawabata, J

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Molecules 2007, 12(1), 86-97; doi:10.3390/12010086

Article

Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase

Hong Gao, Jun Nishida, Shizuka Saito and Jun Kawabata*

Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan

* Author to whom correspondence should be addressed.

Received: 8 December 2006; in revised form: 24 January 2007 / Accepted: 24 January 2007 / Published: 29 January 2007

(This article belongs to the Special Issue Phenolics and Polyphenolics)

Download PDF Full-Text [138 KB, uploaded 20 June 2008 16:50 CEST]

Abstract: Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA,while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor tomonophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity andwas a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, weconclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agentswith inhibitory effects in addition to their antioxidant properties.

Keywords: Tyrosinase inhibitor; flavonoids; 5;6;7-trihydroxyflavones; baicalein; melanin; depigmentation.

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