Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof

doi:10.3390/11090707

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Molecules 2006, 11(9), 707-713; doi:10.3390/11090707

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Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof

Samuël Demin, Dirk Van Haver and Pierre J. De Clercq*

Ghent University, Department of Organic Chemistry, Laboratory for Organic Synthesis, Krijgslaan 281 (S4), B-9000 Gent, Belgium

* Author to whom correspondence should be addressed.

Received: 7 September 2006; in revised form: 14 September 2006 / Accepted: 14 September 2006 / Published: 18 September 2006

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Abstract: The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.

Keywords: Asymmetric synthesis; Meyers' bicyclic lactam template; hydrindenones.

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MDPI and ACS Style

Demin, S.; Van Haver, D.; De Clercq, P.J. Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof. Molecules 2006, 11, 707-713.

AMA Style

Demin S, Van Haver D, De Clercq PJ. Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof. Molecules. 2006; 11(9):707-713.

Chicago/Turabian Style

Demin, Samuël; Van Haver, Dirk; De Clercq, Pierre J. 2006. "Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof." Molecules 11, no. 9: 707-713.

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