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Molecules 2006, 11(7), 574-582; doi:10.3390/11070574

Synthesis and Anticancer Activities of Novel 1,4-Disubstituted Phthalazines

,  and *
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China
* Author to whom correspondence should be addressed.
Received: 25 June 2006 / Revised: 12 July 2006 / Accepted: 13 July 2006 / Published: 27 July 2006
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A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4- difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4- (3,4-difluorophenyl-thiomethyl)phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method.
Keywords: Phthalazine derivatives; synthesis; anticancer activities. Phthalazine derivatives; synthesis; anticancer activities.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, J.; Zhao, Y.-F.; Yuan, X.-Y.; Xu, J.-X.; Gong, P. Synthesis and Anticancer Activities of Novel 1,4-Disubstituted Phthalazines. Molecules 2006, 11, 574-582.

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