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Molecules 2006, 11(5), 334-344; doi:10.3390/11050334
Article

An Improved NMR Study of Liposomes Using 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine as Model

1, 1,* , 1, 3 and 1
1 Istituto di Metodologie Chimiche, CNR, 00016 Monterotondo Stazione, Roma, Italy 2 Dipartimento S.T.A.A.M, Università degli Studi del Molise, 86100 Campobasso, Italy 3 Dipartimento di Fisica, Università di Roma "La Sapienza", piazz. A. Moro, 2, 00185 Roma, Italy and Istituto Nazionale per la Fisica della Materia (INFM), Unità di Roma1, Roma, Italy
* Author to whom correspondence should be addressed.
Received: 15 April 2006 / Accepted: 9 May 2006 / Published: 10 May 2006
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Abstract

In this paper we report a comparative characterization of Small UnilamellarVesicles (SUVs), Large Unilamellar Vesicles (LUVs) and Multilamellar Vesicles (MLVs)prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine (POPC), carried outusing two NMR techniques, namely High Resolution NMR in solution and HighResolution–Magic Angle Spinning (HR-MAS). The size and size distributions of thesevesicles were investigated using the dynamic light scattering technique. An improvedassignment of the 1H-NMR spectrum of MLVs is also reported.
Keywords: Liposomes; unilamellar vesicles; multilamellar vesicles; NMR; HR-MAS; dynamic light scattering Liposomes; unilamellar vesicles; multilamellar vesicles; NMR; HR-MAS; dynamic light scattering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cruciani, O.; Mannina, L.; Sobolev, A.P.; Cametti, C.; Segre, A. An Improved NMR Study of Liposomes Using 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine as Model. Molecules 2006, 11, 334-344.

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