Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

doi:10.3390/11040286

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Molecules 2006, 11(4), 286-297; doi:10.3390/11040286

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Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

Petr Knesl, Dirk Röseling and Ulrich Jordis*

Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria

* Author to whom correspondence should be addressed.

Received: 9 March 2006 / Accepted: 10 April 2006 / Published: 10 April 2006

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Abstract: The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

Keywords: Quinazolines; tyrosine kinase inhibitors.

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MDPI and ACS Style

Knesl, P.; Röseling, D.; Jordis, U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules 2006, 11, 286-297.

AMA Style

Knesl P, Röseling D, Jordis U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules. 2006; 11(4):286-297.

Chicago/Turabian Style

Knesl, Petr; Röseling, Dirk; Jordis, Ulrich. 2006. "Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib." Molecules 11, no. 4: 286-297.

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