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Molecules 2006, 11(4), 286-297; doi:10.3390/11040286
Article

Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

,  and *
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 9 March 2006 / Accepted: 10 April 2006 / Published: 10 April 2006
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Abstract

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.
Keywords: Quinazolines; tyrosine kinase inhibitors. Quinazolines; tyrosine kinase inhibitors.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Knesl, P.; Röseling, D.; Jordis, U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules 2006, 11, 286-297.

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