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Molecules 2006, 11(4), 286-297; doi:10.3390/11040286
Article

Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

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Received: 9 March 2006; Accepted: 10 April 2006 / Published: 10 April 2006
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Abstract: The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.
Keywords: Quinazolines; tyrosine kinase inhibitors. Quinazolines; tyrosine kinase inhibitors.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Knesl, P.; Röseling, D.; Jordis, U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules 2006, 11, 286-297.

AMA Style

Knesl P, Röseling D, Jordis U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules. 2006; 11(4):286-297.

Chicago/Turabian Style

Knesl, Petr; Röseling, Dirk; Jordis, Ulrich. 2006. "Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib." Molecules 11, no. 4: 286-297.


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