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Molecules 2006, 11(4), 286-297; doi:10.3390/11040286

Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

,  and *
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 9 March 2006 / Accepted: 10 April 2006 / Published: 10 April 2006
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The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.
Keywords: Quinazolines; tyrosine kinase inhibitors. Quinazolines; tyrosine kinase inhibitors.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Knesl, P.; Röseling, D.; Jordis, U. Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib. Molecules 2006, 11, 286-297.

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