Molecules 2005, 10(9), 1197-1208; doi:10.3390/10091197
Article

Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives

1 Departamento de Química. Universidad Nacional de Río Cuarto, Argentina 2 Departamento de Química Orgánica. Facultad de Química – Facultad de Ciencias. Universidad de la República, Uruguay 3 Departamento de Química Inorgánica y Analítica. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile, Chile
* Author to whom correspondence should be addressed.
Received: 2 December 2004; in revised form: 8 July 2005 / Accepted: 9 July 2005 / Published: 30 September 2005
PDF Full-text Download PDF Full-Text [161 KB, uploaded 20 June 2008 16:49 CEST]
Abstract: The relationship between the herbicidal activity of a number of novel 1,2,5-oxadiazole N-oxides and some physicochemical properties potentially related with thisbioactivity, such as polarity, molecular volume, proton acceptor ability, lipophilicity, andreduction potential were studied. The semiempirical molecular orbital method AM1 wasused to calculate theoretical descriptors such as dipolar moment, molecular volume,Mulliken ́s charge and the octanol/water partition coefficients (log Po/w). The values ofthe reduction potentials (Er) were obtained by cyclic voltammetry. In addition, theretention factors (log k’w) on a reversed-phase high-performance liquid chromatography(RP-HPLC) column in pure aqueous mobile phases were measured for several N-oxidederivatives. The log k’w values show good correlation with the calculated values of logPo/w, showing that the chromatographic parameter can be used as lipophilicity descriptorfor these compounds. The multiple regression analysis between the descriptors for the N-oxide derivatives and the herbicide activity indicate that the variance in the biologicalactivity can be explained by changes in the lipophilicity and in the reduction potential.
Keywords: 1; 2; 5-Oxadiazole N-oxide derivatives; herbicides; lipophilicity

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Fernandez, L.; Santo, M.; Reta, M.; Giacomelli, L.; Cattana, R.; Silber, J.; Risso, M.; Cerecetto, H.; Gonzalez, M.; Olea-Azar, C. Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives. Molecules 2005, 10, 1197-1208.

AMA Style

Fernandez L, Santo M, Reta M, Giacomelli L, Cattana R, Silber J, Risso M, Cerecetto H, Gonzalez M, Olea-Azar C. Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives. Molecules. 2005; 10(9):1197-1208.

Chicago/Turabian Style

Fernandez, L.; Santo, M.; Reta, M.; Giacomelli, L.; Cattana, R.; Silber, J.; Risso, M.; Cerecetto, H.; Gonzalez, M.; Olea-Azar, C. 2005. "Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives." Molecules 10, no. 9: 1197-1208.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert