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Molecules 2005, 10(8), 922-928; doi:10.3390/10080922
Article

Investigation of Antioxidant Vitamins (A, E, C) and Lipid Peroxidation Levels in Rats Injected N-(1,3-Benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine

1,* , 2, 1, 3, 1 and 1
1 Department of Chemistry, College of Science, Firat University, Elazig 23119, Turkey 2 Elazig School of Health Sciences, Firat University, Elazig 23119, Turkey 3 Faculty of Medicine, Department of Chest Diseases, Firat University, Elazig 23119, Turkey
* Author to whom correspondence should be addressed.
Received: 4 September 2004 / Revised: 16 March 2005 / Accepted: 20 March 2005 / Published: 31 August 2005
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Abstract

The present study examined the influence of synthetic N-(1,3-benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine (2-Amdz) on levels of vitamins A, E and C and malondialdehyde (MDA) in rats. A total of 30 rats, divided into two groups, were used in the study. The control group was given only a subcutaneous injection of 250 ?L 75% ethanol, every other day. The other group of rats was administered a subcutaneous injection of 2-Amdz (25 mg kg-1, dissolved in 250 ?L of 75% ethanol). Injections were continued for 16 days. After the application of 2-Amdz for 16 days, the serum levels of vitamins A, E and C and malondialdehyde (MDA) were determined by HPLC. The serum vitamin A, E, and C levels decreased significantly compared to controls (p<0.05) whereas serum MDA levels were higher than control levels (p<0.005). As a result, it can be suggested that 2-Amdz induced a severe stress and more importantly, increased the amount of free radicals and significantly decreased the levels of serum antioxidant vitamins.
Keywords: N-(1; 3-Benzothiazol-2-yl)-N-(4; 5-dihydro-1H-imidazol-2-yl)amine; antioxidant vitamins; MDA and HPLC N-(1; 3-Benzothiazol-2-yl)-N-(4; 5-dihydro-1H-imidazol-2-yl)amine; antioxidant vitamins; MDA and HPLC
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Karatas, F.; Kara, H.; Servi, S.; Tug, T.; Erulas, F.A.; Koca, M. Investigation of Antioxidant Vitamins (A, E, C) and Lipid Peroxidation Levels in Rats Injected N-(1,3-Benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine. Molecules 2005, 10, 922-928.

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