Molecules 2005, 10(7), 783-793; doi:10.3390/10070783

Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity

1,* email, 2, 3 and 4
Received: 9 November 2004; in revised form: 4 March 2005 / Accepted: 10 March 2005 / Published: 31 August 2005
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
Keywords: 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity
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MDPI and ACS Style

Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.

AMA Style

Vinsova J, Horak V, Buchta V, Kaustova J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules. 2005; 10(7):783-793.

Chicago/Turabian Style

Vinsova, Jarmila; Horak, Václav; Buchta, Vladimir; Kaustova, Jarmila. 2005. "Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity." Molecules 10, no. 7: 783-793.

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