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Molecules 2005, 10(7), 783-793; doi:10.3390/10070783
Article

Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity

1,* , 2, 3 and 4
1 Department of Inorganic and Organic Chemistry, Faculty of Pharmacy Charles University, 500 05 Hradec Králové, The Czech Republic 2 Georgetown University, Washington DC 20057-1227, USA 3 Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Prague, Czech Republic 4 National Reference Laboratory for Mycobacterium Kansasii, Regional Institute of Hygiene, Ostrava, The Czech Republic
* Author to whom correspondence should be addressed.
Received: 9 November 2004 / Revised: 4 March 2005 / Accepted: 10 March 2005 / Published: 31 August 2005
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Abstract

A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
Keywords: 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.

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