Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
AbstractA series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
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Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.
Vinsova J, Horak V, Buchta V, Kaustova J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules. 2005; 10(7):783-793.Chicago/Turabian Style
Vinsova, Jarmila; Horak, Václav; Buchta, Vladimir; Kaustova, Jarmila. 2005. "Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity." Molecules 10, no. 7: 783-793.