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Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy Charles University, 500 05 Hradec Králové, The Czech Republic
Georgetown University, Washington DC 20057-1227, USA
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Prague, Czech Republic
National Reference Laboratory for Mycobacterium Kansasii, Regional Institute of Hygiene, Ostrava, The Czech Republic
* Author to whom correspondence should be addressed.
Received: 9 November 2004; in revised form: 4 March 2005 / Accepted: 10 March 2005 / Published: 31 August 2005
Abstract: A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
Keywords: 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity
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MDPI and ACS Style
Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.
Vinsova J, Horak V, Buchta V, Kaustova J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules. 2005; 10(7):783-793.
Vinsova, Jarmila; Horak, Václav; Buchta, Vladimir; Kaustova, Jarmila. 2005. "Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity." Molecules 10, no. 7: 783-793.