Open AccessThis article is
- freely available
Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy Charles University, 500 05 Hradec Králové, The Czech Republic
Georgetown University, Washington DC 20057-1227, USA
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Prague, Czech Republic
National Reference Laboratory for Mycobacterium Kansasii, Regional Institute of Hygiene, Ostrava, The Czech Republic
* Author to whom correspondence should be addressed.
Received: 9 November 2004; in revised form: 4 March 2005 / Accepted: 10 March 2005 / Published: 31 August 2005
Abstract: A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
Keywords: 3; 5-di-tert-Butyl-1; 2-benzoquinone; 5; 7-di-tert-butylbenzoxazoles; antimyco- bacterial activity; antifungal activity
Citations to this Article
Cite This Article
MDPI and ACS Style
Vinsova, J.; Horak, V.; Buchta, V.; Kaustova, J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules 2005, 10, 783-793.
Vinsova J, Horak V, Buchta V, Kaustova J. Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity. Molecules. 2005; 10(7):783-793.
Vinsova, Jarmila; Horak, Václav; Buchta, Vladimir; Kaustova, Jarmila. 2005. "Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity." Molecules 10, no. 7: 783-793.