Molecules 2005, 10(10), 1298-1306; doi:10.3390/10101298
Article

Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region

1 Department of Chemistry, University of Podlasie, 3-Maja 54, Siedlce, Poland 2 Department of Biophysics, University of Warmia & Mazury, 4 Oczapowskiego St., Olsztyn, Poland
* Author to whom correspondence should be addressed.
Received: 12 April 2005; Accepted: 10 July 2005 / Published: 31 October 2005
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Abstract: Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. Theabsorption spectrum of some 5-substituted derivatives was found to extend to the visibleregion. These compounds were found to inhibit some enzymes of purine metabolism, likexanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10-3 –10-5 M range.
Keywords: Pyrazolo[4; 3-e][1; 2; 4]triazines; purine analogues; enzyme inhibitors.

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MDPI and ACS Style

Mojzych, M.; Rykowski, A.; Wierzchowski, J. Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region. Molecules 2005, 10, 1298-1306.

AMA Style

Mojzych M, Rykowski A, Wierzchowski J. Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region. Molecules. 2005; 10(10):1298-1306.

Chicago/Turabian Style

Mojzych, Mariusz; Rykowski, Andrzej; Wierzchowski, Jacek. 2005. "Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region." Molecules 10, no. 10: 1298-1306.

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