Next Article in Journal
Eco-friendly Oxidative Iodination of Various Arenes with Sodium Percarbonate as the Oxidant†
Previous Article in Journal
9-Hydroxyfurodysinin-O-ethyl Lactone: A New Sesquiterpene Isolated from the Tropical Marine Sponge Dysidea arenaria
Article Menu

Export Article

Open AccessArticle
Molecules 2005, 10(10), 1298-1306; doi:10.3390/10101298

Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region

1
Department of Chemistry, University of Podlasie, 3-Maja 54, Siedlce, Poland
2
Department of Biophysics, University of Warmia & Mazury, 4 Oczapowskiego St., Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Received: 12 April 2005 / Accepted: 10 July 2005 / Published: 31 October 2005
View Full-Text   |   Download PDF [139 KB, uploaded 18 June 2014]   |  

Abstract

Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. Theabsorption spectrum of some 5-substituted derivatives was found to extend to the visibleregion. These compounds were found to inhibit some enzymes of purine metabolism, likexanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10-3 –10-5 M range. View Full-Text
Keywords: Pyrazolo[4; 3-e][1; 2; 4]triazines; purine analogues; enzyme inhibitors. Pyrazolo[4; 3-e][1; 2; 4]triazines; purine analogues; enzyme inhibitors.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mojzych, M.; Rykowski, A.; Wierzchowski, J. Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region. Molecules 2005, 10, 1298-1306.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top