Next Article in Journal / Special Issue
Fragrance Release from the Surface of Branched Poly (Amide) S
Previous Article in Journal / Special Issue
Polymers for DNA Delivery
Article Menu

Article Versions

Export Article

Open AccessReview
Molecules 2005, 10(1), 65-80; doi:10.3390/10010065

Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs

1
School of Pharmacy, 30, Quai E. Ansermet, CH-1211 Geneva 4, Switzerland
2
Centro Galénico, Farmacia y Tecnología Farmacéutica, Universidad de Navarra; Ap. 177, 31080 – Pamplona, Spain
*
Author to whom correspondence should be addressed.
Received: 28 May 2004 / Accepted: 7 July 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)
View Full-Text   |   Download PDF [2588 KB, uploaded 18 June 2014]   |  

Abstract

Oral administration remains the most convenient way of delivering drugs. Recent advances in biotechnology have produced highly potent new molecules such as peptides, proteins and nucleic acids. Due to their sensitivity to chemical and enzymatic hydrolysis as well as a poor cellular uptake, their oral bioavailability remains very low. Despite sophisticated new delivery systems, the development of a satisfactory oral formulation remains a challenge. Among the possible strategies to improve the absorption of drugs, micro- and nanoparticles represent an exciting approach to enhance the uptake and transport of orally administered molecules. Increasing attention has been paid to their potential use as carriers for peptide drugs for oral administration. This article reviews the most common manufacturing methods for polymeric particles and the physiology of particle absorption from the gastrointestinal (GI) tract. In a second part, the use of polymeric particulate systems to improve the oral absorption of insulin is discussed.
Keywords: Nanoparticle; microparticle; oral route; peptide; mechanisms of absorption; protein; insulin; calcitonin. Nanoparticle; microparticle; oral route; peptide; mechanisms of absorption; protein; insulin; calcitonin.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Delie, F.; Blanco-Príeto, M.J. Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs. Molecules 2005, 10, 65-80.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top