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Molecules 2005, 10(1), 259-264; doi:10.3390/10010259
Article

Synthesis of the Key Precursor of Hirsutellide A

1, 1, 1, 1, 1, 1 and 1,*
Received: 27 February 2004; Accepted: 19 March 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
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Abstract: Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
Keywords: Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xu, Y.; Duan, X.; Li, M.; Jiang, L.; Zhao, G.; Meng, Y.; Chen, L. Synthesis of the Key Precursor of Hirsutellide A. Molecules 2005, 10, 259-264.

AMA Style

Xu Y, Duan X, Li M, Jiang L, Zhao G, Meng Y, Chen L. Synthesis of the Key Precursor of Hirsutellide A. Molecules. 2005; 10(1):259-264.

Chicago/Turabian Style

Xu, Yanjie; Duan, Xuemin; Li, Meiling; Jiang, Liqin; Zhao, Guangle; Meng, Yi; Chen, Ligong. 2005. "Synthesis of the Key Precursor of Hirsutellide A." Molecules 10, no. 1: 259-264.


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