Synthesis of the Key Precursor of Hirsutellide A

doi:10.3390/10010259

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Molecules 2005, 10(1), 259-264; doi:10.3390/10010259

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Synthesis of the Key Precursor of Hirsutellide A

Yanjie Xu¹, Xuemin Duan¹, Meiling Li¹, Liqin Jiang¹, Guangle Zhao¹, Yi Meng¹ and Ligong Chen^1,*

¹ College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, P.R. China ² Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen, 518055, P.R. China

* Author to whom correspondence should be addressed.

Received: 27 February 2004 / Accepted: 19 March 2004 / Published: 31 January 2005

(This article belongs to the Special Issue Hypervalent Iodine)

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Abstract: Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.

Keywords: Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection

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Cite This Article

MDPI and ACS Style

Xu, Y.; Duan, X.; Li, M.; Jiang, L.; Zhao, G.; Meng, Y.; Chen, L. Synthesis of the Key Precursor of Hirsutellide A. Molecules 2005, 10, 259-264.

AMA Style

Xu Y, Duan X, Li M, Jiang L, Zhao G, Meng Y, Chen L. Synthesis of the Key Precursor of Hirsutellide A. Molecules. 2005; 10(1):259-264.

Chicago/Turabian Style

Xu, Yanjie; Duan, Xuemin; Li, Meiling; Jiang, Liqin; Zhao, Guangle; Meng, Yi; Chen, Ligong. 2005. "Synthesis of the Key Precursor of Hirsutellide A." Molecules 10, no. 1: 259-264.

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