Next Article in Journal / Special Issue
Synthesis of Unsymmetrical Annulated 2,2’-Bipyridine Analogues with Attached Cycloalkene and Piperidine Rings via Sequential Diels-Alder Reaction of 5,5’-bi-1,2,4-triazines†
Previous Article in Journal / Special Issue
Synthesis and Molecular Structure of Methyl 4-O-methyl-α-D-glucopyranuronate
Molecules 2005, 10(1), 259-264; doi:10.3390/10010259
Article

Synthesis of the Key Precursor of Hirsutellide A

1, 1, 1, 1, 1, 1 and 1,*
Received: 27 February 2004 / Accepted: 19 March 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
Download PDF [183 KB, uploaded 18 June 2014]

Abstract

Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
Keywords: Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Xu, Y.; Duan, X.; Li, M.; Jiang, L.; Zhao, G.; Meng, Y.; Chen, L. Synthesis of the Key Precursor of Hirsutellide A. Molecules 2005, 10, 259-264.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert