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Molecules 2005, 10(1), 259-264; doi:10.3390/10010259
Article

Synthesis of the Key Precursor of Hirsutellide A

1, 1, 1, 1, 1, 1 and 1,*
1 College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, 300072, P.R. China 2 Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen, 518055, P.R. China
* Author to whom correspondence should be addressed.
Received: 27 February 2004 / Accepted: 19 March 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
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Abstract

Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
Keywords: Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection Hirsutellide A; linear hexadepsipeptide; coupled reagent; diazotization hydrolysis; Boc protection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Xu, Y.; Duan, X.; Li, M.; Jiang, L.; Zhao, G.; Meng, Y.; Chen, L. Synthesis of the Key Precursor of Hirsutellide A. Molecules 2005, 10, 259-264.

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