Next Article in Journal
Factoid Question Answering with Distant Supervision
Previous Article in Journal
Complexity Analysis of Global Temperature Time Series
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Entropy 2018, 20(6), 438; https://doi.org/10.3390/e20060438

Analysis of Cell Signal Transduction Based on Kullback–Leibler Divergence: Channel Capacity and Conservation of Its Production Rate during Cascade

1
Clinical Research Center for Medical Equipment Development, Kyoto University Hospital, Shogoin-Kawahara-cho 54, Sakyo-ku, Kyoto 606-8057, Japan
2
Department of Drug Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8315, Japan
Received: 17 May 2018 / Revised: 26 May 2018 / Accepted: 3 June 2018 / Published: 5 June 2018
(This article belongs to the Section Information Theory)
View Full-Text   |   Download PDF [797 KB, uploaded 6 June 2018]   |  

Abstract

Kullback–Leibler divergence (KLD) is a type of extended mutual entropy, which is used as a measure of information gain when transferring from a prior distribution to a posterior distribution. In this study, KLD is applied to the thermodynamic analysis of cell signal transduction cascade and serves an alternative to mutual entropy. When KLD is minimized, the divergence is given by the ratio of the prior selection probability of the signaling molecule to the posterior selection probability. Moreover, the information gain during the entire channel is shown to be adequately described by average KLD production rate. Thus, this approach provides a framework for the quantitative analysis of signal transduction. Moreover, the proposed approach can identify an effective cascade for a signaling network. View Full-Text
Keywords: average entropy production rate; fluctuation theorem; signal transduction average entropy production rate; fluctuation theorem; signal transduction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tsuruyama, T. Analysis of Cell Signal Transduction Based on Kullback–Leibler Divergence: Channel Capacity and Conservation of Its Production Rate during Cascade. Entropy 2018, 20, 438.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Entropy EISSN 1099-4300 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top