Next Article in Journal
Where There is Life There is Mind: In Support of a Strong Life-Mind Continuity Thesis
Previous Article in Journal
A Study of the Transfer Entropy Networks on Industrial Electricity Consumption
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Entropy 2017, 19(4), 167; doi:10.3390/e19040167

Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle

1
Department of Bioinformatics and Telemedicine, Collegium Medium, Jagiellonian University, Lazarza 16, 31-530 Krakow, Poland
2
Chair of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 7, 31-034 Krakow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Raúl Alcaraz Martínez
Received: 6 March 2017 / Revised: 7 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
(This article belongs to the Section Information Theory)
View Full-Text   |   Download PDF [9194 KB, uploaded 14 April 2017]   |  

Abstract

We propose a mathematical model describing the formation of micellar forms—whether spherical, globular, cylindrical, or ribbonlike—as well as its adaptation to protein structure. Our model, based on the fuzzy oil drop paradigm, assumes that in a spherical micelle the distribution of hydrophobicity produced by the alignment of polar molecules with the external water environment can be modeled by a 3D Gaussian function. Perturbing this function by changing the values of its sigma parameters leads to a variety of conformations—the model is therefore applicable to globular, cylindrical, and ribbonlike micelles. In the context of protein structures ranging from globular to ribbonlike, our model can explain the emergence of fibrillar forms; particularly amyloids. View Full-Text
Keywords: spherical micelle; cylindrical micelle; ribbonlike micelle; fuzzy oil drop model; amyloid; divergence entropy spherical micelle; cylindrical micelle; ribbonlike micelle; fuzzy oil drop model; amyloid; divergence entropy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Roterman, I.; Banach, M.; Konieczny, L. Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle. Entropy 2017, 19, 167.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Entropy EISSN 1099-4300 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top