Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle
AbstractWe propose a mathematical model describing the formation of micellar forms—whether spherical, globular, cylindrical, or ribbonlike—as well as its adaptation to protein structure. Our model, based on the fuzzy oil drop paradigm, assumes that in a spherical micelle the distribution of hydrophobicity produced by the alignment of polar molecules with the external water environment can be modeled by a 3D Gaussian function. Perturbing this function by changing the values of its sigma parameters leads to a variety of conformations—the model is therefore applicable to globular, cylindrical, and ribbonlike micelles. In the context of protein structures ranging from globular to ribbonlike, our model can explain the emergence of fibrillar forms; particularly amyloids. View Full-Text
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Roterman, I.; Banach, M.; Konieczny, L. Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle. Entropy 2017, 19, 167.
Roterman I, Banach M, Konieczny L. Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle. Entropy. 2017; 19(4):167.Chicago/Turabian Style
Roterman, Irena; Banach, Mateusz; Konieczny, Leszek. 2017. "Application of the Fuzzy Oil Drop Model Describes Amyloid as a Ribbonlike Micelle." Entropy 19, no. 4: 167.
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