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Entropy 2014, 16(9), 4923-4936; doi:10.3390/e16094923

Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors

Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China
Department of Mechanics, College of Sciences, Shanghai University, Shanghai 200444, China
College of Mechanical Engineering, Changzhou University, Changzhou 213016, China
Author to whom correspondence should be addressed.
Received: 26 May 2014 / Revised: 21 July 2014 / Accepted: 25 August 2014 / Published: 15 September 2014
(This article belongs to the Special Issue Entropy in Experimental Design, Sensor Placement, Inquiry and Search)
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An entropy-controlled bending mechanism is presented to study the nanomechanics of microcantilever-based single-stranded DNA (ssDNA) sensors. First; the conformational free energy of the ssDNA layer is given with an improved scaling theory of thermal blobs considering the curvature effect; and the mechanical energy of the non-biological layer is described by Zhang’s two-variable method for laminated beams. Then; an analytical model for static deflections of ssDNA microcantilevers is formulated by the principle of minimum energy. The comparisons of deflections predicted by the proposed model; Utz–Begley’s model and Hagan’s model are also examined. Numerical results show that the conformational entropy effect on microcantilever deflections cannot be ignored; especially at the conditions of high packing density or long chain systems; and the variation of deflection predicted by the proposed analytical model not only accords with that observed in the related experiments qualitatively; but also appears quantitatively closer to the experimental values than that by the preexisting models. In order to improve the sensitivity of static-mode biosensors; it should be as small as possible to reduce the substrate stiffness. View Full-Text
Keywords: biosensor; conformational entropy; principle of minimum energy; two-variable method biosensor; conformational entropy; principle of minimum energy; two-variable method

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tan, Z.-Q.; Zhang, N.-H. Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors. Entropy 2014, 16, 4923-4936.

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