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Entropy 2013, 15(9), 3822-3876; doi:10.3390/e15093822

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

1
Internal Medicine Group Practice, PhyNet, Inc., 4002 Technology Center, Longview, TX 75605, USA
2
Independent Researcher, Houston, TX 77084, USA
3
Computer Science and Artificial Intelligence Laboratory, MIT, 32 Vassar Street, Cambridge, MA 02139, USA
Note added by the Publisher: The editors of the journal have been alerted to concerns over potential bias in opinions and bias in the choice of citation sources used in this article. We note that the authors stand by the content as published. Since the nature of the claims against the paper concern speculation and opinion, and not fraud or academic misconduct, the editors would like to issue an Expression of Concern to make readers aware that the approach to collating literature citations for this article was likely not systematic and may not reflect the spectrum of opinions on the issues covered by the article. Please refer to our policy regarding <a href='http://www.mdpi.com/about/controversial-articles'>possibly controversial articles.
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Author to whom correspondence should be addressed.
Received: 3 June 2013 / Revised: 26 August 2013 / Accepted: 30 August 2013 / Published: 13 September 2013
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Abstract

This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the “problems” of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater “stiffness” in the extracellular matrix and either the “soft” cancerous state or the “soft” neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. View Full-Text
Keywords: aluminum; entropy; toxicants; carcinogens; heparan sulfate proteoglycans; breast cancer; hydrophobic effect; interphase; interfacial water stress; lymphoma; magnetized water; ovarian cancer; pancreatic cancer; lung cancer; water nanoclusters aluminum; entropy; toxicants; carcinogens; heparan sulfate proteoglycans; breast cancer; hydrophobic effect; interphase; interfacial water stress; lymphoma; magnetized water; ovarian cancer; pancreatic cancer; lung cancer; water nanoclusters
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Davidson, R.M.; Lauritzen, A.; Seneff, S. Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases. Entropy 2013, 15, 3822-3876.

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