Entropy 2013, 15(9), 3822-3876; doi:10.3390/e15093822
Review

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

1,* email, 2email and 3email
Received: 3 June 2013; in revised form: 26 August 2013 / Accepted: 30 August 2013 / Published: 13 September 2013
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Abstract: This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the “problems” of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater “stiffness” in the extracellular matrix and either the “soft” cancerous state or the “soft” neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal.
Keywords: aluminum; entropy; toxicants; carcinogens; heparan sulfate proteoglycans; breast cancer; hydrophobic effect; interphase; interfacial water stress; lymphoma; magnetized water; ovarian cancer; pancreatic cancer; lung cancer; water nanoclusters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Davidson, R.M.; Lauritzen, A.; Seneff, S. Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases. Entropy 2013, 15, 3822-3876.

AMA Style

Davidson RM, Lauritzen A, Seneff S. Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases. Entropy. 2013; 15(9):3822-3876.

Chicago/Turabian Style

Davidson, Robert M.; Lauritzen, Ann; Seneff, Stephanie. 2013. "Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases." Entropy 15, no. 9: 3822-3876.


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