Next Article in Journal / Special Issue
Learning Genetic Population Structures Using Minimization of Stochastic Complexity
Previous Article in Journal
Functional Information: Towards Synthesis of Biosemiotics and Cybernetics
Entropy 2010, 12(5), 1071-1101; doi:10.3390/e12051071
Article

On the Interplay between Entropy and Robustness of Gene Regulatory Networks

*  and
Laboratory of Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan
* Author to whom correspondence should be addressed.
Received: 2 March 2010 / Revised: 10 April 2010 / Accepted: 28 April 2010 / Published: 4 May 2010
(This article belongs to the Special Issue Entropy in Genetics and Computational Biology)
View Full-Text   |   Download PDF [362 KB, uploaded 24 February 2015]   |   Browse Figures
SciFeed

Abstract

The interplay between entropy and robustness of gene network is a core mechanism of systems biology. The entropy is a measure of randomness or disorder of a physical system due to random parameter fluctuation and environmental noises in gene regulatory networks. The robustness of a gene regulatory network, which can be measured as the ability to tolerate the random parameter fluctuation and to attenuate the effect of environmental noise, will be discussed from the robust H stabilization and filtering perspective. In this review, we will also discuss their balancing roles in evolution and potential applications in systems and synthetic biology.
Keywords: entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Chen, B.-S.; Li, C.-W. On the Interplay between Entropy and Robustness of Gene Regulatory Networks. Entropy 2010, 12, 1071-1101.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Entropy EISSN 1099-4300 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert