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Entropy 2010, 12(5), 1071-1101; doi:10.3390/e12051071
Article

On the Interplay between Entropy and Robustness of Gene Regulatory Networks

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Received: 2 March 2010 / Revised: 10 April 2010 / Accepted: 28 April 2010 / Published: 4 May 2010
(This article belongs to the Special Issue Entropy in Genetics and Computational Biology)
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Abstract

The interplay between entropy and robustness of gene network is a core mechanism of systems biology. The entropy is a measure of randomness or disorder of a physical system due to random parameter fluctuation and environmental noises in gene regulatory networks. The robustness of a gene regulatory network, which can be measured as the ability to tolerate the random parameter fluctuation and to attenuate the effect of environmental noise, will be discussed from the robust H stabilization and filtering perspective. In this review, we will also discuss their balancing roles in evolution and potential applications in systems and synthetic biology.
Keywords: entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, B.-S.; Li, C.-W. On the Interplay between Entropy and Robustness of Gene Regulatory Networks. Entropy 2010, 12, 1071-1101.

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