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Entropy 2010, 12(5), 1071-1101; doi:10.3390/e12051071

On the Interplay between Entropy and Robustness of Gene Regulatory Networks

Laboratory of Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan
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Received: 2 March 2010 / Revised: 10 April 2010 / Accepted: 28 April 2010 / Published: 4 May 2010
(This article belongs to the Special Issue Entropy in Genetics and Computational Biology)
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Abstract

The interplay between entropy and robustness of gene network is a core mechanism of systems biology. The entropy is a measure of randomness or disorder of a physical system due to random parameter fluctuation and environmental noises in gene regulatory networks. The robustness of a gene regulatory network, which can be measured as the ability to tolerate the random parameter fluctuation and to attenuate the effect of environmental noise, will be discussed from the robust H stabilization and filtering perspective. In this review, we will also discuss their balancing roles in evolution and potential applications in systems and synthetic biology. View Full-Text
Keywords: entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering entropy robustness; kinetic parameter fluctuation; random noise; evolution of gene network; synthetic gene network; systems and synthetic biology; robust H stabilization and filtering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, B.-S.; Li, C.-W. On the Interplay between Entropy and Robustness of Gene Regulatory Networks. Entropy 2010, 12, 1071-1101.

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