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New Insights into Immune and Anti-inflammatory Strategies for Improving Human Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 583

Special Issue Editor


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Guest Editor
Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: autoimmunity; osteoarthritis; B cells; T cells; cell signaling; mouse models
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Special Issue Information

Dear Colleagues,

It is evolutionarily determined that the immune system copes with the harmful effects of viruses and bacteria, as well as the development of autoimmune and tumor processes. Managing these health challenges successfully relies on a multitude of distinct and specific cells, the complexity of immune system components (including innate, humoral, and cellular), and the interplay of complex genetic and environmental factors. The principles that control the immune response to infection manifest in many normal physiological processes and in autoimmunity, making them applicable to cancer treatment.

The current Special Issue will attempt to provide a comprehensive overview of recent developments in the field of immunology and inflammation management. Our goal is to organize a collection of cutting-edge research and expert perspectives (original research articles, short communications, and reviews) that shed light on innovative approaches for immune activation, modulation, and tolerance in the context of immune and anti-inflammatory therapies to improve human health.

Dr. Nikolina Mihaylova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • immunotherapy
  • autoimmune disease
  • cancer
  • immune activation
  • modulation
  • tolerance

Published Papers (1 paper)

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Research

16 pages, 3876 KiB  
Article
Gene Expression and Metabolome Analysis Reveals Anti-Inflammatory Impacts of 11,17diHDoPE on PM10-Induced Mouse Lung Inflammation
by Uijin Kim, Dong-Hyuk Kim, Deok-Kun Oh, Ha Youn Shin and Choong Hwan Lee
Int. J. Mol. Sci. 2024, 25(10), 5360; https://doi.org/10.3390/ijms25105360 - 14 May 2024
Viewed by 233
Abstract
Oxylipins, the metabolites of polyunsaturated fatty acids, are vital in regulating cell proliferation and inflammation. Among these oxylipins, specialized pro-resolving mediators notably contribute to inflammation resolution. Previously, we showed that the specialized pro-resolving mediators isomer 11,17dihydroxy docosapentaenoic acid (11,17diHDoPE) can be synthesized in [...] Read more.
Oxylipins, the metabolites of polyunsaturated fatty acids, are vital in regulating cell proliferation and inflammation. Among these oxylipins, specialized pro-resolving mediators notably contribute to inflammation resolution. Previously, we showed that the specialized pro-resolving mediators isomer 11,17dihydroxy docosapentaenoic acid (11,17diHDoPE) can be synthesized in bacterial cells and exhibits anti-inflammatory effects in mammalian cells. This study investigates the in vivo impact of 11,17diHDoPE in mice exposed to particulate matter 10 (PM10). Our results indicate that 11,17diHDoPE significantly mitigates PM10-induced lung inflammation in mice, as evidenced by reduced pro-inflammatory cytokines and pulmonary inflammation-related gene expression. Metabolomic analysis reveals that 11,17diHDoPE modulates inflammation-related metabolites such as threonine, 2-keto gluconic acid, butanoic acid, and methyl oleate in lung tissues. In addition, 11,17diHDoPE upregulates the LA-derived oxylipin pathway and downregulates arachidonic acid- and docosahexaenoic acid-derived oxylipin pathways in serum. Correlation analyses between gene expression and metabolite changes suggest that 11,17diHDoPE alleviates inflammation by interfering with macrophage differentiation. These findings underscore the in vivo role of 11,17diHDoPE in reducing pulmonary inflammation, highlighting its potential as a therapeutic agent for respiratory diseases. Full article
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