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Implication of Nanoparticles in Cancer Therapy Research 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1323

Special Issue Editors

Department of Life and Environmental Physics, Horia Hulubei National Institute of Physics and Nuclear Engineering, 077125 Magurele, Romania
Interests: radioresistant cancer cell biology; tumor cell radiosensitization; DNA damage signaling; mitochondria–nucleus communication; radiation-induced bystander effects; radiation response biomarkers; tumor microenvironment
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Guest Editor
“Horia Hulubei” National Insitute of Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Street, 077125 Magurele, Romania
Interests: nanobiomaterials; drug delivery; cancer therapy; radiobiology; biocompatibility
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Clinically employed classical cancer therapies can cause unselective damage to healthy tissue. A growing body of research used nanotechnology to find strategies to overcome this disadvantage. Current research is focused on developing innovative therapies based on novel nanoparticles that enhance the therapeutic effect of chemotherapy and radiotherapy in order to reduce toxicity. Typical nanoparticles possess a wide range of physicochemical and biological properties including nano range size (less than 100 nm), a large surface area to volume ratio, specific structural properties, the ability to carry specific agents on their surface, the capacity to form stable interactions with ligands, the ability to overcome cellular or tissue barriers and to circulate in the blood for a long time, enhanced electrical conductivity, superparamagnetic behavior, the energy absorption, unique fluorescence properties. These features allow nanoparticles to facilitate drug delivery, multimodality treatment, and theranostics (combined therapy and diagnostic).

In this Special Issue, we expect contributions from a broad community of scientists working on developing new strategies based on nanoparticles to improve cancer chemotherapy/radiotherapy.

More published papers could be found in the closed Special Issue: Implication of Nanoparticles in Cancer Therapy Research.

Dr. Diana Savu
Dr. Roxana Cristina Popescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • nanoparticles
  • nanocarriers
  • drug delivery
  • cancer therapy

Published Papers (1 paper)

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Review

21 pages, 1354 KiB  
Review
Dual Implications of Nanosilver-Induced Autophagy: Nanotoxicity and Anti-Cancer Effects
by Lidia Strużyńska
Int. J. Mol. Sci. 2023, 24(20), 15386; https://doi.org/10.3390/ijms242015386 - 20 Oct 2023
Viewed by 971
Abstract
In recent years, efforts have been made to identify new anti-cancer therapies. Various types of nanomaterials, including silver nanoparticles (AgNPs), are being considered as an option. In addition to its well-known antibacterial activity, AgNPs exhibit cytotoxic potential in both physiological and cancer cells [...] Read more.
In recent years, efforts have been made to identify new anti-cancer therapies. Various types of nanomaterials, including silver nanoparticles (AgNPs), are being considered as an option. In addition to its well-known antibacterial activity, AgNPs exhibit cytotoxic potential in both physiological and cancer cells by inducing stress-mediated autophagy and apoptotic cell death. A rapidly growing collection of data suggests that the proper regulation of autophagic machinery may provide an efficient tool for suppressing the development of cancer. In this light, AgNPs have emerged as a potential anti-cancer agent to support therapy of the disease. This review summarizes current data indicating the dual role of AgNP-induced autophagy and highlights factors that may influence its protective vs. its toxic potential. It also stresses that our understanding of the cellular and molecular mechanisms of autophagy machinery in cancer cells, as well as AgNP-triggered autophagy in both normal and diseased cells, remains insufficient. Full article
(This article belongs to the Special Issue Implication of Nanoparticles in Cancer Therapy Research 2.0)
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