Polygenic Risk Scores for Complex Traits in the Genome-Wide Association Study (GWAS) Era
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (29 April 2024) | Viewed by 1035
Special Issue Editor
Interests: genomics and transcriptomics of Mendelian and complex traits; association and Linkage analyses; statistical genetics and bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Genetic and polygenic risk scores from genome studies are becoming reliable predictors for the assessment of the genetic risk of complex traits/diseases. In the era of precision medicine, there is a compelling interest in building novel and more precise computational models to predict the intricate network of gene–gene and gene–environment interactions underlying the etiopathological pathways of complex traits. The introduction of polygenic risk scores represents a relatively novel field of genetic research that has its roots in the present-day ability to determine individual genomic profiles at low cost. Such profiles can be arranged into complex models to synthesize the association of new composite genetic factors with many complex diseases. In this Special Issue, we welcome contributions focusing on genetic and polygenic risk scores, comprising their development and implementation and their application in human traits and diseases.
Dr. Giovanni Malerba
Guest Editor
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Keywords
- precision medicine
- genetic
- gene–gene
- gene–environment