Adverse Neonatal Outcomes in Perinatal Periods: Risk Factors, Screening and Treatment

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Neonatology".

Deadline for manuscript submissions: 5 July 2024 | Viewed by 1596

Special Issue Editors


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Guest Editor
Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
Interests: neonatology; growth and nutrition in very low birth weight infants; sedation in the NICU; renal failure in the NICU; microbiom

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Guest Editor
Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel
Interests: neonatology; congenital CMV infection; nutrition and breast milk in preterm infants

Special Issue Information

Dear Colleagues,

Preterm birth affects approximately 15 million infants each year, and accounts for around 11% of live births worldwide. While modern neonatology has improved survival rates in the smallest and sickest infants, these infants are susceptible to a wide range of long-term adverse outcomes. Long term consequences may include impairments in the respiratory and cardiovascular systems (bronchopulmonary dysplasia and right heart failure), chronic kidney disease, sub-optimal growth and feeding issues, short bowel syndrome, late-life cardiometabolic disease and psychological and psychosocial long-lasting issues.

In terms of cognitive and neurodevelopmental impairment including vision and hearing impairments, preterm infants are at an increased risk of developmental delays, intellectual disabilities, learning difficulties, and behavioral disorders.

A multidisciplinary collaboration and holistic approach to extremely preterm infants may allow better follow-up and improve long term outcomes.

Dr. Noa Ofek-Shlomai
Dr. Smadar Eventov-Friedman
Guest Editors

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Keywords

  • prematurity
  • very low birth weight
  • neurodevelopmental impairment
  • adverse outcome

Published Papers (1 paper)

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Research

9 pages, 908 KiB  
Article
The Most Valuable Predictive Factors for Bronchopulmonary Dysplasia in Very Preterm Infants
by Wenwen Chen, Zhenhai Zhang, Liping Xu and Chao Chen
Children 2023, 10(8), 1373; https://doi.org/10.3390/children10081373 - 11 Aug 2023
Viewed by 1271
Abstract
Introduction: It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as Ureaplasma Urealyticum (UU) infection and chest radiograph images. Methods: A retrospective study was performed. Moderate [...] Read more.
Introduction: It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as Ureaplasma Urealyticum (UU) infection and chest radiograph images. Methods: A retrospective study was performed. Moderate to severe BPD or death was set as the main outcome. The association between putative variables and the main outcome were assessed by bivariate analyses and logistic regression. Results: A total of 134 infants were enrolled. Bivariate analyses showed the gestational age, birth weight, appearances of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies on chest radiographic images, a ductal diameter ≥1.5 mm and whether UU infection was associated with BPD. After adjustment by logistic regression, the risk of BPD with gestational age, sex and specific chest-radiographic manifestations remained significant. Conclusions: Chest radiograph images (appearance of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies) could provide a quick prediction of developing BPD in clinical practice, in addition to gestational age and sex. UU infection was not an independent risk factor for BPD. Full article
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