Metabolic Regulation of Hematopoietic Stem Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 1213
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hematopoietic stem cells (HSCs) are a rare population of cells residing in the bone marrow microenvironment, where they preserve the capacity to self-renew and regenerate the whole hematopoietic system during their prolonged lifespan by balancing long-term HSC survival with a demand-adapted response to stress. The decisions to self-renew or to commit to differentiation are critical to generating sufficient numbers of both HSCs and progenies while preventing HSC exhaustion. The transition from quiescence to activation is accompanied by major metabolic and mitochondrial changes that are important for cell cycle entry for balanced decisions between self-renewal and differentiation.
Cellular metabolism is a key regulator of HSC maintenance. HSCs rely on anaerobic glycolysis for energy production to minimize the production of reactive oxygen species and shift toward mitochondrial oxidative phosphorylation upon differentiation. Dysregulated energy metabolism is one possible mechanism underlying HSC defects in various hematological diseases, including bone marrow failure syndromes and leukemia.
This Special Issue will examine the metabolic regulation of HSCs, metabolic changes upon aging or damage, diet-derived metabolites, and novel models to investigate metabolic alterations under physiological or disease conditions.
Dr. Wei Du
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hematopoietic stem cells
- metabolic regulation
- mitochondrial function
- self-renewal and differentiation
- quiescence
- energy metabolism
- HSC exhaustion
- aging
- bm niche
- leukemia stem cells (LSCs)
