Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.1
4.7
Journals
Viruses
Special Issues
Research Progress on Porcine Reproductive and Respiratory Syndrome Virus
share announcement

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 819

Special Issue Editors

Dr. Tongqing An

E-Mail Website
Guest Editor
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
Interests: PRRSV; PRV; molecular epidemiology; vaccine; diagnosis
Special Issues, Collections and Topics in MDPI journals
Dr. Xingyang Cui

E-Mail
Guest Editor
College of Animal Science, Wenzhou Vocational College of Science and Technology, Wenzhou, China
Interests: PRRSV; genetic evolution; vaccine; diagnose

Special Issue Information

Dear Colleagues,

We are delighted to invite you to submit your next publication to this Special Issue of the journal Viruses. Porcine reproductive and respiratory syndrome (PRRS) caused tremendous economic losses to the global swine industry since first being reported in 1987, and current control technologies are still unsatisfactory in preventing the disease. PRRSV is marked by extensive genetic variation introducing new challenges for prevention, and it also leads to secondary bacterial infections with more serious clinical symptoms and higher mortality. PRRSV works via modulating cellular processes, including inflammatory cytokines, innate immunity, apoptosis, etc. This Special Issue will focus on the genetic evolution, replication regulation, immunological or pathogenic mechanisms and vaccine development relating to PRRSV. Original research articles and reviews are welcome.

Dr. Tongqing An
Dr. Xingyang Cui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PRRSV
  • genetic evolution
  • replication regulation
  • immunological or pathogenic mechanism
  • vaccine development
  • prevention and control

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 3308 KiB  
Article
Fidelity Characterization of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and NADC30-like Strain
by Xiang Gao, Ting Bian, Peng Gao, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Lei Zhou and Hanchun Yang
Viruses 2024, 16(5), 797; https://doi.org/10.3390/v16050797 - 16 May 2024
Viewed by 185
Abstract
The porcine reproductive and respiratory syndrome virus (PRRSV) has significantly impacted the global pork industry for over three decades. Its high mutation rates and frequent recombination greatly intensifies its epidemic and threat. To explore the fidelity characterization of Chinese highly pathogenic PRRSV JXwn06 [...] Read more.
The porcine reproductive and respiratory syndrome virus (PRRSV) has significantly impacted the global pork industry for over three decades. Its high mutation rates and frequent recombination greatly intensifies its epidemic and threat. To explore the fidelity characterization of Chinese highly pathogenic PRRSV JXwn06 and the NADC30-like strain CHsx1401, self-recombination and mutation in PAMs, MARC-145 cells, and pigs were assessed. In vitro, CHsx1401 displayed a higher frequency of recombination junctions and a greater diversity of junction types than JXwn06. In vivo, CHsx1401 exhibited fewer junction types yet maintained a higher junction frequency. Notably, JXwn06 showed more accumulation of mutations. To pinpoint the genomic regions influencing their fidelity, chimeric viruses were constructed, with the exchanged nsp9-10 regions between JXwn06 and CHsx1401. The SJn9n10 strain, which incorporates JXwn06’s nsp9-10 into the CHsx1401 genome, demonstrated reduced sensitivity to nucleotide analogs compared to CHsx1401. Conversely, compared with JXwn06, the JSn9n10 strain showed increased sensitivity to these inhibitors. The swapped nsp9-10 also influences the junction frequency and accumulated mutations as their donor strains. The results indicate a propensity for different types of genetic variations between these two strains and further highlight the nsp9-10 region as a critical determinant of their fidelity. Full article
(This article belongs to the Special Issue Research Progress on Porcine Reproductive and Respiratory Syndrome Virus)
►▼ Show Figures

Figure 1

15 pages, 1922 KiB  
Article
Prevalence, Time of Infection, and Diversity of Porcine Reproductive and Respiratory Syndrome Virus in China
by Chaosi Li, Aihua Fan, Zhicheng Liu, Gang Wang, Lei Zhou, Hongliang Zhang, Lv Huang, Jianfeng Zhang, Zhendong Zhang and Yan Zhang
Viruses 2024, 16(5), 774; https://doi.org/10.3390/v16050774 - 13 May 2024
Viewed by 289
Abstract
Porcine reproductive and respiratory syndrome virus (PRRVS) is a major swine viral pathogen that affects the pig industry worldwide. Control of early PRRSV infection is essential, and different types of PRRSV-positive samples can reflect the time point of PRRSV infection. This study aims [...] Read more.
Porcine reproductive and respiratory syndrome virus (PRRVS) is a major swine viral pathogen that affects the pig industry worldwide. Control of early PRRSV infection is essential, and different types of PRRSV-positive samples can reflect the time point of PRRSV infection. This study aims to investigate the epidemiological characteristics of PRRSV in China from Q4 2021 to Q4 2022, which will be beneficial for porcine reproductive and respiratory syndrome virus (PRRSV)control in the swine production industry in the future. A total of 7518 samples (of processing fluid, weaning serum, and oral fluid) were collected from 100 intensive pig farms in 21 provinces, which covered all five pig production regions in China, on a quarterly basis starting from the fourth quarter of 2021 and ending on the fourth quarter of 2022. Independent of sample type, 32.1% (2416/7518) of the total samples were PCR-positive for PRRSV, including 73.6% (1780/2416) samples that were positive for wild PRRSV, and the remaining were positive for PRRSV vaccine strains. On the basis of the time of infection, 58.9% suckling piglets (processing fluid) and 30.8% weaning piglets (weaning serum) showed PRRSV infection at an early stage (approximately 90% of the farms). The sequencing analysis results indicate a wide range of diverse PRRSV wild strains in China, with lineage 1 as the dominant strain. Our study clearly demonstrates the prevalence, infection stage, and diversity of PRRSV in China. This study provides useful data for the epidemiological understanding of PRRSV, which can contribute to the strategic and systematic prevention and control of PRRSV in China. Full article
(This article belongs to the Special Issue Research Progress on Porcine Reproductive and Respiratory Syndrome Virus)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop