Search Results (19)

Background: Functional single ventricle (FSV) comprises a heterogeneous group of congenital heart diseases (CHDs) with severe and complex abnormalities. The multifactorial etiology of the disease poses challenges in identifying specific pathogenic factors and planning effective interventions and preventive treatments for patients. Methods: Whole-exome sequencing (WES) was performed to identify variants in relevant genes in 29 FSV patients from different families. Results: In total, 95 heterozygous variants across 48 CHD-associated genes were identified, including 85 missense, four small indel, one splicing, one stop gain, and four synonymous variants. Among them, 22 were novels, 11 conflicting, and four pathogenic variants. Each patient carried from two to six variants in different genes, including at least one variant in genes associated with serious heart defects such as AXIN1, BMP2, COL6A2, GATA4, GATA5, GDF1, MESP1, MYH6, NFATC1, NKX2-6, NOTCH1, PCSK9, TBX1, TBX18, and TBX20. In addition, the variants in the COL6A1, CREBBP, DOCK6, EOGT, EP300, LRP2, MYBPC3, MYH7, SEMA3C, and ZFPM2 genes are associated with characteristic phenotypes of FSV, such as atrial septal defect, ventricular septal defect, small left heart syndrome, transposition of the great arteries, and double outlet right ventricle occurring at high frequency in patients. The prediction results suggest that these are potentially pathogenic variants in patients and may explain the phenotype in patients. Conclusions: This is the first study to identify variants associated with functional single ventricle, a complex form of congenital heart disease. Our results contribute to a general understanding of the causes of the disease, thereby guiding treatment and prevention approaches for patients. Full article

Objectives: This study aims to describe the clinical features and genetic findings of nine Vietnamese patients with autosomal recessive bestrophinopathy. Methods: This retrospective and cross-sectional study included individuals diagnosed with autosomal recessive bestrophinopathy at the Eye Clinic, Vietnam National Geriatric Hospital between May 2024 and April 2025. The patients underwent a visual acuity assessment, retinal multimodal imaging, and molecular testing through BEST1 gene sequencing. Results: Nine patients from seven unrelated families were included. The mean age was 38.6 years (range: 14.1–79.6). Visual acuity ranged from 20/20 to 20/125. All patients showed vitelliform lesions, subretinal deposits, and both intraretinal and subretinal fluid. Other main features included diffuse macular hyperfluorescence and hyperopia. Less common clinical features encompassed glaucoma, retinoschisis, outer retinal thinning, serous retinal detachment, retinal thickening, and thinning of the retinal pigment epithelium. Compound heterozygous or homozygous variants were detected in all patients. Among the five identified BEST1 variants, the most frequent were p.(A195V) and p.(R200*). One novel variant, p.(K289*), was detected. Conclusions: The main clinical retinal features of nine Vietnamese patients with autosomal recessive bestrophinopathy included vitelliform lesions, subretinal deposits, retinal fluid, and diffuse macular hyperfluorescence. The most common variants were p.(A195V) and p.(R200*). Additionally, the identification of various compound heterozygotes and a novel BEST1 variant expands the mutation spectrum of the disease. Full article

A One Health cross-sectoral surveillance approach was implemented to screen biological samples from bats, pigs, and humans at high-risk interfaces for zoonotic viral spillover for five viral families with zoonotic potential in Viet Nam. Over 1600 animal and human samples from bat guano harvesting sites, natural bat roosts, and pig farming operations were tested for coronaviruses (CoVs), paramyxoviruses, influenza viruses, filoviruses and flaviviruses using consensus PCR assays. Human samples were also tested using immunoassays to detect antibodies against eight virus groups. Significant viral diversity, including CoVs closely related to ancestors of pig pathogens, was detected in bats roosting at the human–animal interfaces, illustrating the high risk for CoV spillover from bats to pigs in Viet Nam, where pig density is very high. Season and reproductive period were significantly associated with the detection of bat CoVs, with site-specific effects. Phylogeographic analysis indicated localized viral transmission among pig farms. Our limited human sampling did not detect any known zoonotic bat viruses in human communities living close to the bat cave and harvesting bat guano, but our serological assays showed possible previous exposure to Marburg virus-like (Filoviridae), Crimean–Congo hemorrhagic fever virus-like (Bunyaviridae) viruses and flaviviruses. Targeted and coordinated One Health surveillance helped uncover this viral pathogen emergence hotspot. Full article

Active magnetic bearings (AMBs) are electromagnetic mechanism systems in which non-contact bearings support a rotating shaft using attractive forces generated by electromagnets through closed-loop control. For complete support of a five degree of freedom (DOF) rotor system, most AMB structures include two radial actuators and one for the axial direction. Conical active magnetic bearings (CAMBs) is one of the development directions of conventional magnetic bearings in which the requirement of the axial bearing can be eliminated. In this paper, we propose a structure with a CAMB integrated into a canned motor pump to eliminate the need for mechanical bearings and shaft seals. However, this system necessitates a more complicated control strategy due to a significant coupling effect between rotor motion and hydrodynamic disturbances. This paper presents a fractional order active disturbance rejection control (FOADRC) including a fractional order extend state observer (FOESO) and a proportional derivative controller (PD) to track and reject lumped disturbances actively. The proposed controller achieves better performance than the integer-type ADRC and traditional PID controller. The control performance of the proposed FOADRC is illustrated in terms of very good disturbance rejection capability that is demonstrated through MATLAB/Simulink simulation results. Full article

Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam. Full article

In recent years, both scientists and local governments have been giving serious attention to land evaluation, especially in regard to the use of agricultural land. This is with the intention of increasing the sustainability of agricultural production. In Vietnam, acacia plantations play an important role in the livelihoods of farmers in mountainous regions. Therefore, identifying suitable areas for acacia plantations is an important consideration within mountainous areas. This research was conducted in Nam Dong district, Central Vietnam, using six physical soil criteria for land evaluation by the Analytic Hierarchy Process (AHP) and also the Fuzzy Analytic Hierarchy Process (FAHP). The results have shown that the ranking of selected criteria in both methods was the same, but the weighting of each criterion was different. Among the six physical soil criteria, soil depth has the highest priority, followed by slope, soil organic carbon content, soil texture, soil pH, and soil type. The suitability maps for acacia plantations within the area studied have shown that 9344 ha were not suitable, and 99 ha had low suitability for acacia plantation by both methods. For the AHP approach, 928 hectares were in the range of moderate suitability, and 3080 hectares were in the high suitability class. In contrast, the FAHP method determined 905 hectares to be of the moderate suitability class and 3102 hectares to be of the high suitability class. Based on the observed acacia’s productivity and the scores of the two methods, it shows that the FAHP has a stronger correlation than the of AHP. Within the six selected criteria, the FAHP method can increase the accuracy of land evaluation results by 4.62% in comparison to the original AHP method. Therefore, the FAHP is the most suitable method for land evaluation, especially for agricultural land planning. Further studies should be integrated into more social and economic criteria for comprehensive land evaluation scenarios. Full article

Art therapy has been widely offered to reduce symptoms of psychological disturbance. Pooled evidence about its effectiveness in epidemic contexts, particularly during the COVID-19 pandemic, has not been yet established. This study reviewed the effectiveness, feasibility, and acceptability of art therapy on children and adolescents during the COVID-19 pandemic and past epidemics. We searched PubMed/Medline, PsycINFO, CENTRAL (Cochrane Library), and CINAHL for articles on art therapy during COVID-19. Included studies reported improvements in measures of mental health, sleep quality, and psychological well-being in children with or without disabilities in the epidemic context. Results also showed that art therapy was highly feasible and accepted by children and adolescents as well as their families during epidemics in reviewed studies. Art therapy can be effective at improving various aspects of mental health, sleep quality, and psychological well-being. More empirical evidence is needed with larger sample sizes and longer duration of interventions. Full article

The catalytic effect of red mud on Vietnam anthracite’s combustion characteristics was investigated. The mineralogical composition of the red mud includes CaCO₃, Fe₂O₃, FeO(OH), FeTiO₃, and Al(OH)₃. This red mud is rich in Na, Ca, Al, Fe, and Ti. The combustion characteristics were analyzed by the thermogravimetry method. The combustion effectiveness was assessed by thermogravimetric analysis. The results were derived from a combination of several parameters, such as the ignition temperature, the burnout efficiency, and the amount of heat release. The combustion characteristics of pulverized coal were improved by the introduction of red mud, and the greatest catalytic performance was achieved when the content reached 6%. With the optimal addition, the ignition temperature of anthracite was reduced by 12 °C, and the burnout efficiencies were increased by 2.59% compared to raw anthracite. The amount of heat released by anthracite was increased to 6.93 kJ/g by adding red mud. Full article

Background: Dengue virus and Japanese encephalitis virus are two common flaviviruses that are spread widely by Aedes and Culex mosquitoes. Livestock keeping is vital for cities; however, it can pose the risk of increasing the mosquito population. Our study explored how livestock keeping in and around a large city is associated with the presence of mosquitoes and the risk of them spreading flaviviruses. Methods: An entomological study was conducted in 6 districts with 233 households with livestock, and 280 households without livestock, in Hanoi city. BG-Sentinel traps and CDC light traps were used to collect mosquitoes close to animal farms and human habitats. Adult mosquitoes were counted, identified to species level, and grouped into 385 pools, which were screened for flaviviruses using a pan-flavivirus qPCR protocol and sequencing. Results: A total of 12,861 adult mosquitoes were collected at the 513 households, with 5 different genera collected, of which the Culex genus was the most abundant. Our study found that there was a positive association between livestock keeping and the size of the mosquito population—most predominantly between pig rearing and Culex species (p < 0.001). One pool of Cx. tritaeniorhynchus, collected in a peri-urban district, was found to be positive for Japanese encephalitis virus. Conclusions: The risk of flavivirus transmission in urban areas of Hanoi city due to the spread of Culex and Aedes mosquitoes could be facilitated by livestock keeping. Full article

In this paper, a fuzzy disturbance observer and a high-gain disturbance observer based on a variable structure controller are applied to deal with imprecise multi-shaft with web materials linkage systems taking into account the variation of the moment of inertia. Specifically, a high-gain disturbance observer and an adaptive fuzzy algorithm are separately applied to estimate system uncertainties and external disturbances. The high-gain disturbance observer is designed with auxiliary variables to avoid the amplification of the measurement disturbance, and the fuzzy disturbance observer has the advantage that it does not depend on model information. The convergence properties of the tracking error are analytically proven using Lyapunov’s theory. The obtained numerical results demonstrate the validity and the adaptive performance of the proposed control law in case the system is exposed to uncertainties and disturbances. Important remarks on the design process and performance benchmarks of the two observers are also demonstrated. Full article

Cassava (Manihot esculenta Crantz) is a crucial staple crop, and provides carbohydrate energy to more than half a billion people in the tropics. Cassava mosaic disease (CMD) is the most important disease of cassava in Africa. Since Sri Lanka Cassava Mosaic Virus (SLCMV) was first reported in South East Asia in 2015, establishing sustainable solutions to CMD has become a top priority for the cassava program at the International Center for Tropical Agriculture (CIAT) and its partners. In the present study, we screened two populations for CMD resistance: VNM142, 142 clones collected from farms throughout Vietnam, and CIAT102, 102 clones resistant to CMD or mites, which were introduced from CIAT. High broad-sense heritability was observed in all the trials (>0.80). From the population VNM142, eight clones showed high CMD resistance with CMD severity scores less than 2.0. Two resistant clones had the same DNA fingerprinting with the accessions CR63 (PER262 or TAI9) and KM57 (VNM8) in the genebank, respectively. To our knowledge, this is the first report of CMD resistance in the genebank at CIAT. We also used the two populations to validate the CMD markers S12_7926132 and S14_4626854. Both markers explained 51% of the population variance in the segregating population CIAT102, but only 11% in the diverse population VNM142. Thus, we concluded that the two CMD markers could not be used to select for CMD resistance in diverse populations, but could predict the CMD resistance in segregating populations when the susceptible parents do not have resistant marker alleles and the resistance of the CMD2 donors is confirmed. Full article

Adopting a cross-sectional study design, we aimed to examine the prevalence of psychological problems in different healthcare workers during the COVID-19 pandemic in the hospitals in these COVID-19 hotspots (Da Nang city and Quang Nam province) and to explore the socioeconomic and COVID-19 control-related factors that are associated with various psychological problems. A total of 611 healthcare workers were included in the final analysis from 1 August 2020 to 31 August 2020. The prevalence of anxiety, depression, insomnia, and overall psychological problems was 26.84%, 34.70%, 34.53%, and 46.48%, respectively. The prevalence rates of anxiety were approximately equal amongst the groups of healthcare workers, and moderate-to-severe anxiety was the most common in physicians (11.11%). The prevalence of depression was the highest in nurses (38.65%) and moderate-to-severe depression was mainly found in physicians (11.81%). The prevalence rates of insomnia were 34.03% in physicians, 36.20% in nurses, and 31.21% in technicians; in particular, the rate of moderate-to-severe insomnia was higher in physicians and nurses compared to technicians. The prevalence of overall moderate-to-severe psychological problems was the highest among physicians (14.58%), followed by nurses (12.58%) and technicians (9.22%). Statistically significant associated factors of current psychological problems were the occupations of physicians or nurses, less than 1 year of experience, university education, living with 4–5 people, reporting 1000–5000 m distance between home and workplace, participating in the COVID-19 control for less than 1 week, being under social isolation at home, being affected a lot by the community, reporting inadequate equipment in current workplace conditions, frequently working in the department directly in contact with the COVID-19 patients, and feeling anxious, stressed, or sad about current works. Present findings can provide valuable evidence for the policymakers and managers to adopt supportive, encouraging, motivational, protective, training, and educational interventions into healthcare workforce in other parts of Vietnam. Full article

Flood hazards affect the local economy and the livelihood of residents along the South-Central Coast of Vietnam. Understanding the factors influencing floods’ occurrence potentially contributes to establish mitigation responses to the hazards. This paper deals with an empirical study on applying a combination of the fuzzy analytic hierarchy process (AHP), the fuzzy technique for order of preference by similarity to ideal solution (TOPSIS), and a geographic information system (GIS) to assess flood hazards along the South-Central Coast of Vietnam. Data are collected from focus group discussions (FGDs) with five communal authorities; a questionnaire completed by eight hamlet heads in the Phuoc Thang commune (Binh Dinh province); and documents, reports, and thematic maps provided from official sources. A total of 12 maps of flood factors are prepared. The results show that terrain elevation, creek-bottom terrains, high tide-induced flooding area, and distance to water body are the main factors affecting flood hazards. The An Loi hamlet faces the highest risk for floods, followed by Lac Dien, Luong Binh, and Pho Dong. The map of flood hazards indicates the western part is assessed as low hazard, whereas the eastern part is a very high hazard area. The study findings show that the hybrid approach using GIS-based fuzzy AHP–TOPSIS allows connecting decision makers with the influencing factors of flooding. To mitigate floods, both the Vietnam national government and the Binh Dinh provincial government should integrate natural hazard mitigation into socio-economic development policies. Full article

Falls and recurrent falls cause great health and social consequences in older people. However, these problems are poorly understood in Vietnam. A cross-sectional study was performed at seven hospitals in Thai Binh province, Vietnam, to investigate the individual and environmental factors associated with recurrent falls among elderly patients hospitalized due to fall injuries in Vietnam. A history of recurrent falls within the last 12 months, sociodemographic, health, and clinical characteristics, as well as environmental conditions, were obtained via self-reported interviews. Multivariate logistic and Poisson regression models were used to identify associated factors. Overall, the mean fall episodes in the last 12 months were 1.8 (Standard deviation—SD = 1.2) episodes, and the 12-month prevalence of recurrent falls was 40.5%. The individual risk factors included not receiving fall prevention guidelines, walking with devices, loss of sensation in hand or foot, and using pain relief medications. The environmental risk factors comprised having too-high stairs and not having dry, clean, and nonslippery bathrooms. This study highlights a significantly high 12-month prevalence of recurrent falls in older patients hospitalized after falls in Vietnam. Moreover, regular assessments of functional disabilities and hazardous environmental conditions, as well as the provision of prevention programs, have potential to prevent falls and recurrent falls. Full article

Groundwater is one of the most important sources of fresh water all over the world, especially in those countries where rainfall is erratic, such as Vietnam. Nowadays, machine learning (ML) models are being used for the assessment of groundwater potential of the region. Credal decision trees (CDT) is one of the ML models which has been used in such studies. In the present study, the performance of the CDT has been improved using various ensemble frameworks such as Bagging, Dagging, Decorate, Multiboost, and Random SubSpace. Based on these methods, five hybrid models, namely BCDT, Dagging-CDT, Decorate-CDT, MBCDT, and RSSCDT, were developed and applied for groundwater potential mapping of DakLak province of Vietnam. Data of 227 groundwater wells of the study area were utilized for the construction and validation of the models. Twelve groundwater potential conditioning factors, namely rainfall, slope, elevation, river density, Sediment Transport Index (STI), curvature, flow direction, aspect, soil, land use, Topographic Wetness Index (TWI), and geology, were considered for the model studies. Various statistical measures, including area under receiver operating characteristic (AUC) curve, were applied to validate and compare the performance of the models. The results show that performance of the hybrid CDT ensemble models MBCDT (AUC = 0.770), BCDT (AUC = 0.731), Dagging-CDT (AUC = 0.763), Decorate-CDT (AUC = 0.750), and RSSCDT (AUC = 0.766) improved significantly in comparison to the single CDT (AUC = 0.722) model. Therefore, these developed hybrid models can be applied for better ground water potential mapping and groundwater resources management of the study area as well as other regions of the world. Full article