Search Results (4)

Background/Objectives: Early attachment experiences and psychopathology both shape individuals’ emotion processing. However, the specific influence of adult attachment representations on self- (intrapersonal) and other-focused (interpersonal) emotion processing remains unclear, particularly in the context of personality disorders. This study examined how attachment representations (organized vs. unresolved) modulate intrapersonal emotion perception (“impathy”) and interpersonal emotion recognition while accounting for personality pathology. Methods: Thirty-three adults (twenty-four patients with a personality disorder and nine healthy controls) were assessed for attachment representation using the Adult Attachment Projective Picture System (AAP). Emotion processing was measured via the Impathy Inventory and a facial emotion recognition task (READ-64). Group differences (organized vs. unresolved attachment; patients vs. controls) and correlations with the severity of unresolved attachment status were analyzed. Results: Patients with organized attachment representations did not differ from healthy controls in emotion recognition but showed significantly reduced impathy (M difference = −21.72, SE = 6.20, p = 0.002, 95% CI [−34.42, −9.01], d = −1.57). In contrast, patients with unresolved attachment exhibited impairments in both intrapersonal (M difference = −32.99, SE = 6.20, p < 0.001, 95% CI [−45.69, −20.29], d = −2.39) and interpersonal (M difference = −12.37, SE = 4.36, p = 0.008, 95% CI [−21.28, −3.46], d = −1.23) emotion processing compared to healthy controls. Furthermore, the severity of unresolved attachment status correlated with greater impairment in recognizing anger (r = −0.74, p = 0.004). Conclusions: An organized attachment representation may act as a protective factor, preserving interpersonal emotion recognition even in the presence of psychopathology. Conversely, an unresolved attachment constitutes an additional risk factor that exacerbates emotion processing impairments in the context of personality pathology. Attachment representation thus emerges as an active modulator of core emotion processes, with important implications for theory and targeted interventions in personality disorders. Full article

The attachment representation (AR) of individuals affects emotional and cognitive information processes and is considered an important modulating factor of neuroendocrine stress responses. The neuropeptide oxytocin is studied as one biomolecular component underpinning this modulation. A validated procedure used in attachment-related research is the Adult Attachment Projective Picture System (AAP). To date, only a limited number of studies investigated oxytocin and neuroendocrine reactivity in the context of an attachment-related stimulus similar to the APP. In this pilot study, N = 26 men of recent fatherhood were exposed to the AAP to classify AR and to investigate salivary changes in oxytocin, cortisol and dehydroepiandrosterone (DHEA) after AAP stimulation. We observed increased oxytocin levels in response to AAP exposure, and this increase was more pronounced in fathers with unresolved/disorganized AR. No significant changes in cortisol and DHEA concentrations were observed in response to AAP administration. Interestingly, differences in basal cortisol levels (before the AAP) also depended on AR classification. Here, the group of men with unresolved/disorganized AR showed higher levels of cortisol compared to fathers with organized AR. To conclude, the finding of increased salivary oxytocin levels in response to the AAP further indicates its validity as an instrument to stimulate the attachment system. Full article

Emerging data suggest that obesity is a major risk factor for the progression of major complications such as acute respiratory distress syndrome (ARDS), cytokine storm and coagulopathy in COVID-19. Understanding the mechanisms underlying the link between obesity and disease severity as a result of SARS-CoV-2 infection is crucial for the development of new therapeutic interventions and preventive measures in this high-risk group. We propose that multiple features of obesity contribute to the prevalence of severe COVID-19 and complications. First, viral entry can be facilitated by the upregulation of viral entry receptors, like angiotensin-converting enzyme 2 (ACE2), among others. Second, obesity-induced chronic inflammation and disruptions of insulin and leptin signaling can result in impaired viral clearance and a disproportionate or hyper-inflammatory response, which together with elevated ferritin levels can be a direct cause for ARDS and cytokine storm. Third, the negative consequences of obesity on blood coagulation can contribute to the progression of thrombus formation and hemorrhage. In this review we first summarize clinical findings on the relationship between obesity and COVID-19 disease severity and then further discuss potential mechanisms that could explain the risk for major complications in patients suffering from obesity. Full article

Wheat is one of the most consumed cereal grains worldwide and makes up a substantial part of the human diet. Although government-supported dietary guidelines in Europe and the U.S.A advise individuals to eat adequate amounts of (whole) grain products per day, cereal grains contain “anti-nutrients,” such as wheat gluten and wheat lectin, that in humans can elicit dysfunction and disease. In this review we discuss evidence from in vitro, in vivo and human intervention studies that describe how the consumption of wheat, but also other cereal grains, can contribute to the manifestation of chronic inflammation and autoimmune diseases by increasing intestinal permeability and initiating a pro-inflammatory immune response. Full article