Search Results (36)

Introduction: Prostate cancer is one of the most prevalent malignancies affecting men globally, with a significant impact on health-related quality of life (HRQOL). With the recent therapeutic advancements and improvements in survival, there is a need to understand the determinants of HRQOL in metastatic prostate cancer patients to optimize treatment strategies for quality of life as the number of survivors increases. The aim of this study was to identify clinical variables that affect HRQOL and its domains in patients with metastatic prostate cancer. Methods: We conducted a cross-sectional questionnaire-based study in patients diagnosed with metastatic prostate cancer at a tertiary cancer center in India. Baseline clinical features, treatment details, and completed Functional Assessment of Cancer Therapy—Prostate (FACT-P), composed of FACT-general (FACT-G) and prostate cancer-specific concerns subscale (PCS) and FACT-P Trial Outcome Index (FACT-P TOI) questionnaires, were collected. The mean total, as well as individual domain scores, were calculated. Additionally, these were stratified by the current treatment being received by patients. Linear regression was used to identify independent factors affecting HRQOL in these patients. Results: Of the 106 enrolled patients, 84 completed the FACT-P questionnaire and were included in the analysis. The median age was 66 years, and at the time of assessment, 3 patients (3.6%) were receiving androgen deprivation therapy only, 53 patients (63.1%) were on ADT + androgen receptor-targeted agents (ARTAs), and 18 patients (21.4%) patients received ADT + chemotherapy. The mean (±standard deviation) of the FACT-P TOI score was 70.33 (±15.16); the PCS subscale was the most affected, followed by functional well-being. Patients on chemotherapy scored significantly higher on PCS, but the composite scores were not significantly different. Univariable regression identified obesity (body mass index > 25 kg/m²) and duration of first-line treatment as significant predictors of better HRQOL; however, obesity was the only independent predictor in multivariable analysis (β = 8.2; 95% confidence interval, 1.2 to 15.0; p = 0.022). Obesity also independently predicted a better FACT-P and its physical well-being domain score and PCS. Conclusion: Prostate cancer patients experience impaired QoL, especially in the prostate cancer-specific and functional well-being domains. Lower BMI is an independent predictor of poor QoL, and this requires efforts to assess the impact of strategies to manage the nutritional status of patients with metastatic disease on QoL outcomes. Full article

In the present two-dimensional numerical study, we investigate the roles of geometrical parameters of a hydrofoil (shape/curvature of the leading and trailing edges and thickness) and kinematic parameters (phase difference between heave and pitch ($\varphi$)) on the propulsive performance of different-shaped hydrofoils oscillating at maximum angles of attack up to ${\alpha }_{max}={30}^{\circ }$. The study was carried out at a fixed non-dimensional maximum heave to chord ratio $h_{\circ }/C=0.75$, Strouhal number $St=0.25$, and Reynolds number $Re=5000$. Our findings reveal that hydrofoil performance and stability improve with leading and trailing edge curvatures but decline as thickness increases. By analyzing the near-wake structure, we establish that even minimal flow separation increases power consumption while moderate flow separation enhances thrust. Over the range of different-shaped hydrofoils at different ${\alpha }_{max}$ and $\varphi$, maximum propulsion efficiency occurs for those parameters for which there is a small degree of flow separation but with no roll-up of a separating vortex. In comparison, maximum thrust generation occurs when there is a moderately strong flow separation but without induction of a significant amount of fluid around the trailing edge. These insights offer valuable knowledge for understanding fish propulsion efficiency and have applications in designing autonomous underwater vehicles (AUVs) and micro-air vehicles (MAVs). Full article

Microcapsules of urea-formaldehyde (UF) containing dicyclopentadiene (DCPD) were synthesized by the in situ polymerization technique for self-healing of epoxy. The dispersion of microcapsules in the epoxy matrix was achieved using ultrasonication. Composites of epoxy, having 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules capable of self-healing, were prepared. The shape and size of the microcapsules were determined by field emission electron microscopy. Spherical capsules of DCPD, with an average diameter of 172 nm, were obtained. Investigation of tensile properties indicated a decrease in the tensile modulus with an increase in wt.% of microcapsules. There was a reduction of 22%, 27%, 39%, and 30% in the elastic modulus of composites for 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules, respectively. Tensile strength was found to increase with an increase in wt.% of microcapsules. The tensile strength of the composites increased by 33%, 20%, 8%, and 21% for 0.5, 1.0, 1.5, and 2.0 wt.% of microcapsules, respectively, in comparison with that of neat epoxy. The fatigue life of composites was investigated by conducting uniaxial tension–tension fatigue tests at constant stress amplitudes of 20, 25, 30, and 35 MPa, at a constant stress ratio (R = 0.1) and a frequency of 3 Hz. The fatigue life of composites increased with an increase in wt.% of microcapsules in comparison with that of neat epoxy. It was found that the fatigue life of the composites decreased with 1.5 and 2.0 wt.% of microcapsules in comparison with composites with 0.5 and 1.0 wt.% of microcapsules. The fracture surfaces of the tested samples were examined with the help of scanning electron microscopy (SEM) to understand the various mechanisms responsible for the change in modulus, strength, failure strain, and fatigue life of composites. Full article

Background: Carcinoma penis is a rare neoplasm, and the literature is scarce on long-term survival and its predictors. The aim of the study was to determine the clinical profile and management patterns, identify predictors of survival, and the impact of education and rural/urban dwelling on survival. Methods: Patients with a histological diagnosis of carcinoma penis from January 2015 to December 2019 were included in the study. Demographics, clinical profile, education status, primary residence address, and outcomes were obtained from the case records. Distance from the treatment centre was obtained from the postal code. The primary objectives were to assess relapse-free survival (RFS) and overall survival (OS). The secondary objectives were to identify the predictors of RFS and OS and to determine the clinical profile and treatment patterns in patients with carcinoma penis in India. Time-to-event was calculated by Kaplan–Meir analysis and survival was compared by the log-rank test. Univariate and multivariable Cox regression analyses were used to find independent predictors of relapse and mortality. Logistic regression analyses to examine the associations of rural residence, education status, and distance from the treatment centre with the relapse adjusting for measured confounding variables. Results: Case records of 102 patients treated during the above period were retrieved. The median age was 55.5 (interquartile range [IQR] 42–65 years). Ulcero-proliferative growth (65%), pain (57%), and dysuria (36%) were the most common presenting features. Clinical examination or imaging revealed inguinal lymphadenopathy in 70.6% of patients, however, only 42% of these lesions were pathologically involved. A total of 58.8% of patients were from rural areas, 46.9% had no formal education, and 50.9% had a primary residence ≥100 km from the hospital. Patients with lower education and rural households had higher TNM stages and nodal involvement. Median RFS and OS were 57.6 months (15.8 months to not reached) and 83.9 months (32.5 months to not reached), respectively. On univariate analysis tumor stage, involvement of lymph nodes, T stage, performance status, and albumin was predictive for relapse and survival. However, on multivariate analysis, the stage remained the only predictor of RFS and nodal involvement, and metastatic disease was a predictor of OS. Education status, rural habitation, and distance from the treatment centre were not predictors for relapse or survival. Conclusions: Patients with carcinoma have locally advanced disease at presentation. Rural dwellings and lower education were associated with the advanced stage but did not have a significant bearing on the survival outcomes. The stage at diagnosis and nodal involvement is the most important predictor of RFS and OS. Full article

Being one of the major energy consumers, cooking is a necessary part of daily life. Non renewable cooking fuel sources, such as wood or cow dung cause hazardous pollution and a poor ecosystem worldwide. Over the past few decades, solar-powered cooking has undergone numerous improvements. Solar cooking has been predominantly used as a substitute for reducing oil and gas dependence, increasing environmental sustainability, and reducing global warming threats. This paper talks about the recent development of the box-type solar cooker. The paper discusses the principles and classifications of various parameters that affect the performance, energy, and exergy related to the solar cooking system. In line with the sustainable development goals of the UN agenda 2030 and especially the heed to the accomplishment of SDG 7 and SDG 13, various economic factors, such as the payback period (PP), net present value (NPV), benefit–cost (B–C) ratios, internal rate of return (IRR), levelized cost of heat (LCOH), and levelized cost of cooking a meal (LCCM) have been discussed. The environmental analysis has also been presented to show the overall benefit of solar cooking. The review also focuses on the current development of a box-type solar cooker, its components, and its heat transfer characteristic. Various geometrical modifications, the use of reflectors, and transparent insulating materials that improve cooking have been discussed. The concept of energy storage in the form of Phase change material (Latent heat storage) with the latest studied designs improvements of solar cookers has been obtained to be efficient, which also help in late-evening cooking. It can be said that with better policy implications, the social and economic acceptability of the solar cooker can be achieved. Full article

This paper presents a low-loss, high-transmission, broadside-coupled, transverse, reciprocal, two-port, and nature-inspired Ka-band transition design to move the electromagnetic energy of a rectangular waveguide (RWG) to the microstrip (MS) line. The proposed transition is simple in structure, with an excellent insertion loss, S₁₂/S₂₁, (IL) near −0.40 dB and return loss, S₁₁/S₂₂, of <−21 dB, while the VSWR value is very close to one. Thus, this transition is an outstanding candidate for MIC/MMIC-based millimeter wave, military, and RADAR applications, as well as in wireless and satellite communications as a compatible connector. This transition also provides a bandwidth of 21.50 GHz (23.52–45.0 GHz) for the abovementioned microwave applications, at a <−10 dB return loss (RL). The proposed transition model also exhibits a −15 dB absolute bandwidth of 27.06–23.44 GHz, with an insertion loss < −0.60 dB. Due to a return loss of <−15 dB over an ultra-wide bandwidth, the proposed transition is not only a good candidate for full Ka-band (26–40 GHz) applications but also covers applications for K-band from 23.74 GHz to 26.0 GHz, Q-band applications from 33.0 to 45.0 GHz, and U-band applications from 40.0 GHz to 45 GHz, with approximately 97% power transmission between the transmission lines and only 3% power reflections. The impedance matching at the designed frequency between the RWG and MS line is achieved by flaring one end of the MS line inside the RWG in a fishtail shape, without the need for a quarter-wave/tapered/exponential/Binomial, or multi-section Chebyshev transformer. The main goal of this research was to design a multi-section impedance-transformer-free, simple, and easy-to-fabricate MS line, to share electromagnetic (EM) energy between an MS line and RWG in 30 GHz satellite applications and 30 GHz high-frequency applications, for interconnects screen printed on an organic substrate for flexible, wearable, textile conformal antennas. This work also presents an exact RLC electrical equivalence model of the MS line (fishtail) to RWG transition at 30 GHz. The novelty of this work is that the proposed transition can be used for four microwave bands of electromagnetic energy transmission, with extremely low reflection, and with a compact, simple-design MS line, and simple RWG. Full article

Water contamination due to the presence of lead is one of the leading causes of environmental and health hazards because of poor soil and groundwater waste management. Herein we report the synthesis of functionally modified luminescent carbon quantum dots (CQDs) obtained from watermelon juice as potential nanomaterials for the detection of toxic Pb²⁺ ions in polluted water and cancer cells. By introducing surface passivating ligands such as ethanolamine (EA) and ethylenediamine (ED) in watermelon juice, watermelon-ethanolamine (WMEA)-CQDs and watermelon-ethylenediamine (WMED)-CQDs exhibited a remarkable ~10-fold and ~6-fold increase in fluorescence intensity with respect to non-doped WM-CQDs. The relative fluorescence quantum yields of WMEA-CQDs and WMED-CQDs were found to be 8% and 7%, respectively, in an aqueous medium. Among various functionally-modified CQDs, only WMED-CQDs showed high selectivity towards Pb²⁺ ions with a remarkably good limit of detection (LoD) of 190 pM, which is less than that of the permissible limit (72 nM) in drinking water. The functionally altered WMED-CQDs detected Pb²⁺ metal ions in polluted water and in a human cervical cancer cell line (HeLa), thus advocating new vistas for eco-friendly nanomaterials for their use as diagnostic tools in the environment and biomedical research areas. Full article

Background/Objectives: Globally, the COVID-19 pandemic and its prevention and control policies have impacted maternal and child health (MCH) services. This study documents the challenges faced by patients in accessing MCH services, and the experiences of health care providers in delivering those services during the COVID-19 outbreak, explicitly focusing on the lockdown period in India. Methods: A cross-sectional study (rapid survey) was conducted in 18 districts from 6 states of India during March to June, 2020. The sample size included 540 MCH patients, 18 gynaecologists, 18 paediatricians, 18 district immunisation officers and 108 frontline health workers. Bivariate analysis and multivariable analysis were used to assess the association between sociodemographic characteristics, and challenges faced by the patients. Results: More than one-third of patients (n = 212; 39%) reported that accessing MCH services was a challenge during the lockdown period, with major challenges being transportation-related difficulties (n = 99; 46%) unavailability of hospital-based services (n = 54; 23%) and interrupted outreach health services (n = 39; 18.4%). The supply-side challenges mainly included lack of infrastructural preparedness for outbreak situations, and a shortage of human resources. Conclusions/Recommendations: A holistic approach is required that focuses on both preparedness and response to the outbreak, as well reassignment and reinforcement of health care professionals to continue catering to and maintaining essential MCH services during the pandemic. Full article

This article demonstrates the design and development of WR-15 transition using an antipodal microstrip dipole antenna at a frequency of 60 GHz for space applications. An inline microstrip line to rectangular waveguide (MS-to-RWG) transition is proposed for the V-band (50–75 GHz) functioning. The RF energy is coupled and launched through an antipodal dipole microstrip antenna. Impedance matching and mode matching between the MS line and dipole are achieved by a quarter wave impedance transformer. This results in the better performance of transitions in terms of insertion loss (IL > −0.50 dB) and return loss (RL < −10 dB) for a 40.76% relative bandwidth from 55.57 GHz to 65.76 GHz. The lowest values of IL and RL at 60 GHz are −0.09 dB and −32.05 dB, respectively. A 50 μm thick double-sided etched InP substrate material is used for microstrip antipodal dipole antenna design. A back-to-back designed transition has IL > −0.70 dB and RL < −10 dB from 54.29 GHz to 64.07 GHz. The inline transition design is simple in structure, easy to fabricate, robust, compact, and economic; occupies less space because the transition size is exactly equal to the WR-15 length; and is prepared using an InP substrate with high permittivity of 12.4 and thickness of 50 μm. Thus, the devices have the lowest insertion loss value and lowest return loss (RL) value, of <−31 dB, as compared to earlier designs in the literature. Therefore, the proposed design has the lowest radiation loss (because of thickness) and highest transmission (about 97% power). Easy impedance matching using only a single-step quarter-wave transformer between the antipodal dipole antenna and 50 Ω microstrip line (avoiding the multi-sections’ demand and microstrip line’s tedious complexity) is needed. Since, when the InP dielectric substrate is inserted in WR-15, the waveguide becomes a dielectric-filled waveguide (DFWG), and its characteristics impedance reduces to 143 Ω from 505 Ω at an operating frequency of 60 GHz. In the proposed transition, no ridge waveguide or waveguide back-short is utilized in WR-15. The microstrip line did not contain any via, fence, window, screw, galvanic structure, post, etc. Hence, the transition is suitable for high-data-rate 5G communications, satellite remote sensing, missile navigation, MIC/MMIC circuits’ characterization, and mm-wave applications. The electrical equivalent model of the proposed design has been generated and validated using an RF circuit simulator and was found to have excellent matching. Full article

The large size of a glazed component allows greater access to natural light inside and a wider view of the outdoors while protecting the inside from extreme weather conditions. However, glazed components make buildings energy inefficient compared to opaque components if not designed suitably, and sometimes they create glare discomforts too. In order to protect against excessive natural light and direct sunlight and for privacy, dynamic shading devices are integrated into the glazed façade. In this study, the impact of various glazing and shading design parameters has been investigated by performing uncertainty and sensitivity analyses. The uncertainty analysis indicates that the variance coefficients for the source energy use, lighting energy use, useful daylight illuminance (UDI), and shade-deployed time fraction are in the ranges of 15.04–30.47, 39.05–45.06, 40.57–49.92, and 19.35–52%, respectively. The dispersion in the energy and indoor visual performance is evident by the large variation in the source energy consumption and UDI (500–2000), which vary in the ranges of 250–450 kWh/(m²-year) and 5–90%. Furthermore, a sensitivity analysis identified the window-to-wall ratio (WWR), aspect ratio (ASR), glazing type (Gt), absorptance of the wall (Aw), and shade transmittance (ST) as major influences of the parameters. Each of the identified parameters has a different proportionate impact depending on the façade orientation and performance parameters. Full article

Wound healing is an intricate process of tissue repair or remodeling that occurs in response to injury. Plants and plant-derived bioactive constituents are well explored in the treatment of various types of wounds. Curcumin is a natural polyphenolic substance that has been used since ancient times in Ayurveda for its healing properties, as it reduces inflammation and acts on several healing stages. Several research studies for curcumin delivery at the wound site reported the effectiveness of curcumin in eradicating reactive oxygen species and its ability to enhance the deposition of collagen, granulation tissue formation, and finally, expedite wound contraction. Curcumin has been widely investigated for its wound healing potential but its lower solubility and rapid metabolism, in addition to its shorter plasma half-life, have limited its applications in wound healing. As nanotechnology has proven to be an effective technique to accelerate wound healing by stimulating appropriate mobility through various healing phases, curcumin-loaded nanocarriers are used for targeted delivery at the wound sites. This review highlights the potential of curcumin and its nanoformulations, such as liposomes, nanoparticles, and nano-emulsions, etc. in wound healing. This paper emphasizes the numerous biomedical applications of curcumin which collectively prepare a base for its antibiofilm and wound-healing action. Full article

Hard-magnetic soft materials belong to a class of the highly deformable magneto-active elastomer family of smart materials and provide a promising technology for flexible electronics, soft robots, and functional metamaterials. When hard-magnetic soft actuators are driven by a multiple-step input signal (Heaviside magnetic field signal), the residual oscillations exhibited by the actuator about equilibrium positions may limit their performance and accuracy in practical applications. This work aims at developing a command-shaping scheme for alleviating residual vibrations in a magnetically driven planar hard-magnetic soft actuator. The control scheme is based on the balance of magnetic and elastic forces at a critical point in an oscillation cycle. The equation governing the dynamics of the actuator is devised using the Euler–Lagrange equation. The constitutive behaviour of the hard-magnetic soft material is modeled using the Gent model of hyperelasticity, which accounts for the strain-stiffening effects. The dynamic response of the actuator under a step input signal is obtained by numerically solving the devised dynamic governing equation using MATLAB ODE solver. To demonstrate the applicability of the developed command-shaping scheme, a thorough investigation showing the effect of various parameters such as material damping, the sequence of desired equilibrium positions, and polymer chain extensibility on the performance of the proposed scheme is performed. The designed control scheme is found to be effective in controlling the motion of the hard-magnetic soft actuator at any desired equilibrium position. The present study can find its potential application in the design and development of an open-loop controller for hard-magnetic soft actuators. Full article

Chalcones are secondary metabolites belonging to the flavonoid (C₆-C₃-C₆ system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids. Chalcones and their natural derivatives are important intermediates of the flavonoid biosynthetic pathway. Plants containing chalcones have been used in traditional medicines since antiquity. Chalcones are basically α,β-unsaturated ketones that exert great diversity in pharmacological activities such as antioxidant, anticancer, antimicrobial, antiviral, antitubercular, antiplasmodial, antileishmanial, immunosuppressive, anti-inflammatory, and so on. This review provides an insight into the chemistry, biosynthesis, and occurrence of chalcones from natural sources, particularly dietary and medicinal plants. Furthermore, the pharmacological, pharmacokinetics, and toxicological aspects of naturally occurring chalcone derivatives are also discussed herein. In view of having tremendous pharmacological potential, chalcone scaffolds/chalcone derivatives and bioflavonoids after subtle chemical modification could serve as a reliable platform for natural products-based drug discovery toward promising drug lead molecules/drug candidates. Full article

The design and development of biosensors, analytical devices used to detect various analytes in different matrices, has emerged. Biosensors indicate a biorecognition element with a physicochemical analyzer or detector, i.e., a transducer. In the present scenario, various types of biosensors have been deployed in healthcare and clinical research, for instance, biosensors for blood glucose monitoring. Pathogenic microbes are contributing mediators of numerous infectious diseases that are becoming extremely serious worldwide. The recent outbreak of COVID-19 is one of the most recent examples of such communal and deadly diseases. In efforts to work towards the efficacious treatment of pathogenic viral contagions, a fast and precise detection method is of the utmost importance in biomedical and healthcare sectors for early diagnostics and timely countermeasures. Among various available sensor systems, optical biosensors offer easy-to-use, fast, portable, handy, multiplexed, direct, real-time, and inexpensive diagnosis with the added advantages of specificity and sensitivity. Many progressive concepts and extremely multidisciplinary approaches, including microelectronics, microelectromechanical systems (MEMSs), nanotechnologies, molecular biology, and biotechnology with chemistry, are used to operate optical biosensors. A portable and handheld optical biosensing device would provide fast and reliable results for the identification and quantitation of pathogenic virus particles in each sample. In the modern day, the integration of intelligent nanomaterials in the developed devices provides much more sensitive and highly advanced sensors that may produce the results in no time and eventually help clinicians and doctors enormously. This review accentuates the existing challenges engaged in converting laboratory research to real-world device applications and optical diagnostics methods for virus infections. The review’s background and progress are expected to be insightful to the researchers in the sensor field and facilitate the design and fabrication of optical sensors for life-threatening viruses with broader applicability to any desired pathogens. Full article

This article deals with the dissimilar joining of two different grade Cr-Mo steel (2.25Cr-1Mo: P22 and modified 9Cr-1Mo: P91) for power plant application. The dissimilar butt-welded joint was produced for conventional V groove design by using the gas tungsten arc welding (GTAW) process with the application of an ERNiCrMo-3 Ni-based super alloy filler. A microstructure characterization was performed to measure the inhomogeneity in the microstructure and element diffusion across the interface in a welded joint. The experiments were also performed to evaluate the mechanical properties of the dissimilar welded joint in as-welded (AW) and post-weld heat treatment (PWHT) conditions. An acceptable level of the mechanical properties was obtained for the AW joint. After PWHT, a significant level of the element diffusion across the interface of the weld metal and P22 steel was observed, resulting in heterogeneity in microstructure near the interface, which was also supported by the hardness variation. Inhomogeneity in mechanical properties (impact strength and hardness) was measured across the weldments for the AW joint and was reduced after the PWHT. The tensile test results indicate an acceptable level of tensile properties for the welded joint in both AW and PWHT conditions and failure was noticed in the weak region of the P22 steel instead of the weld metal. Full article