Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate
Abstract
:1. Introduction
2. Hedgehog Signal Is a Critical Regulator of Early Chondrogenesis
3. Central Role of Hedgehog Signaling in Regulation of Growth Plate
3.1. Hh Pathway and Growth Plate Formation
3.2. Hh Pathway Controls Regulation of Growth Plate Differentiation through Interaction with PTH-PTHrP Signaling
3.3. Crosstalk between Hh and Other Signaling Pathways as a Basis for Regulatory Mechanisms of Growth Plate Development and Function
3.3.1. Hh and Wnt/β-Catenin Signaling
3.3.2. Hh and FGF Signaling
3.3.3. Hh and BMP Signaling
3.3.4. Hh Signaling and Angiogenic Factors
3.4. Coupling Role of Hh Signaling Pathway and Intracellular Cholesterol Production in Growth Plate Development
3.5. Hh Pathway and Developmental Contribution of Growth Plate Chondrocytes to Skeletal Bone Formation
4. Aberrant Hedgehog Signaling in Skeletal Disease
4.1. Hedgehog Signalling and Brachydactyly Syndrome
4.2. Hedgehog Signaling and Cartilage Tumorigenesis
4.3. Hedgehog Signaling and Heterotopic Ossification
5. Concluding Remarks
Funding
Acknowledgments
Conflicts of Interest
References
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Haraguchi, R.; Kitazawa, R.; Kohara, Y.; Ikedo, A.; Imai, Y.; Kitazawa, S. Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate. Int. J. Mol. Sci. 2019, 20, 5840. https://doi.org/10.3390/ijms20235840
Haraguchi R, Kitazawa R, Kohara Y, Ikedo A, Imai Y, Kitazawa S. Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate. International Journal of Molecular Sciences. 2019; 20(23):5840. https://doi.org/10.3390/ijms20235840
Chicago/Turabian StyleHaraguchi, Ryuma, Riko Kitazawa, Yukihiro Kohara, Aoi Ikedo, Yuuki Imai, and Sohei Kitazawa. 2019. "Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate" International Journal of Molecular Sciences 20, no. 23: 5840. https://doi.org/10.3390/ijms20235840