Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling
Abstract
:1. Introduction
2. Results
2.1. DUSP Classification into Subfamilies and Evolutionary Conservation
2.2. Expression of Dual Specificity Phosphatases and Protein Kinases in Hematopoietic Cells, Primary and Secondary Lymphoid Organs
2.3. Correlation of Dual Specificity Phosphatase Activity with Protein Kinase Activity in Immune Cells
2.4. Expression Landscape and Signaling Dynamics of DUSPs and Kinases in Activated Immune Cells
3. Discussion
4. Materials and Methods
4.1. Datasets
4.2. DUSP and Kinase Lists for Analysis
4.3. Classification of DUSP Family Members, Domain Analysis and Species Conservation Analysis of DUSP Sequences
4.4. Landscape of DUSPs and Kinases in Immune Cells
4.5. Landscape of DUSPs and Kinases in Primary and Secondary Lymphoid Organs
4.6. Baseline DUSP Interactome
4.7. Landscape of DUSPs and Kinases in Activated Immune Cells
4.8. Functional, Pathway and Network Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
DC | Dendritic cells |
MO | Monocytes |
LPS | Lipopolysaccharides |
DUSP | Dual Specificity Phosphatase |
PK | Protein Kinase |
GO | Gene Ontology |
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DUSP-Protein Kinase Pair (Spearman’s Rank Correlation Coefficient ρ) | Relationship | Known/Novel |
---|---|---|
SSH1-AURKA (0.94) | Aurora Kinase A (AURKA) overexpression increased slingshot kinase 1 (SSH1) expression in breast cancer cells [56] | Known |
DUSP1-MAPK7 (0.79) | DUSP1 gene silencing increased MAPK7 expression in osteosarcoma cells [57] | Known |
DUSP1-MAPK8 (0.82) | DUSP1 gene silencing increased MAPK8 expression in osteosarcoma cells [57] | Known |
DUSP10-MAPK8 (0.81) | DUSP10 (MKP-5) dephosphorylates MAPK8 (JNK) [58] | Known |
Dusp16-Mapk8 (0.83) | DUSP-16 (MKP-7) regulates MAPK8 (JNK) in LPS-activated macrophages [59] | Known |
SSH1-CDK17(0.94) | Novel | |
DUSP12-CLK3(0.97) | Novel | |
SSH1-LMTK2 (0.97) | Novel | |
DUSP12-AURKA (0.96) | Novel | |
Ptpmt1-Mast3 (0.97) | Novel | |
Dusp1-Egfr (0.73) | Novel | |
Dusp16-Lrrk2 (0.86) | Novel | |
Dusp10-Igf1r (0.99) | Novel |
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Subbannayya, Y.; Pinto, S.M.; Bösl, K.; Prasad, T.S.K.; Kandasamy, R.K. Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. Int. J. Mol. Sci. 2019, 20, 2086. https://doi.org/10.3390/ijms20092086
Subbannayya Y, Pinto SM, Bösl K, Prasad TSK, Kandasamy RK. Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. International Journal of Molecular Sciences. 2019; 20(9):2086. https://doi.org/10.3390/ijms20092086
Chicago/Turabian StyleSubbannayya, Yashwanth, Sneha M. Pinto, Korbinian Bösl, T. S. Keshava Prasad, and Richard K. Kandasamy. 2019. "Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling" International Journal of Molecular Sciences 20, no. 9: 2086. https://doi.org/10.3390/ijms20092086