2026 October - 27 articles
Background/Objectives: Donation after circulatory death (DCD) grafts represent an increasingly important source of donor organs for paediatric liver transplantation; however, long-term outcomes remain incompletely defined. We aimed to evaluate long-t...
Background/Objectives: Moderate carbohydrate diets (MCD) and sodium glucose cotransporter 2 inhibitors (SGLT2i) both improve metabolic status and liver injury in metabolic dysfunction-associated steatotic liver disease (MASLD), but the therapeutic ef...
Background: COVID-19 infection has been a major cause of hospitalization and mortality in the United States. Patients with liver cirrhosis may be especially vulnerable to severe outcomes of COVID-19 infection because of immune dysfunction, systemic i...
Nuclear receptor coactivator 4 (NCOA4) is the cargo receptor that mediates ferritinophagy, the selective autophagic degradation of ferritin, thereby controlling iron bioavailability. In the liver, this pathway is essential for iron homeostasis, but i...
Background/Objectives: Treatment allocation for hepatocellular carcinoma (HCC) is a highly complex task that requires multidisciplinary tumor board (MDT) input; however, its accessibility and reliability can vary across the healthcare system. Large l...
Background/Objectives: Mirizzi syndrome (MS) alters biliary anatomy, complicating diagnosis and treatment. We characterized diagnostic pathways in reported cases and compared Csendes type I with types II–V. Methods: PubMed and Scopus were searc...
Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. HCC largely develops in patients with chronic liver diseases, including chronic hepatitis and liver cirrhosis. The surveillance in such patients is extremely importan...
Laparoscopic cholecystectomy is among the most frequent abdominal operations worldwide, and its safety has improved across three decades. Major vascular injury nonetheless remains a rare but disproportionately lethal complication, capable of producin...
Background and Objectives: Patients with decompensated cirrhosis often present with multiple concurrent complications, but the prognostic value of the cumulative complication burden remains unclear. This study evaluated the association between the nu...
Background: Uveal melanoma (UM) typically metastasizes to the liver for yet unclear reasons. Hepatic steatosis influences metastasis in several cancer entities, and increased lipid synthesis and metabolism in the cancer tissue promotes tumor progress...
Objective: Advanced fibrosis is the best predictor of future severe liver outcomes in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Our study aims to determine the association between cardiovascular disease (CVD) wit...
Background: Biliary complications represent the most frequent and clinically relevant adverse events after liver transplantation, contributing substantially to morbidity, graft dysfunction, and reduced patient survival. Methods: We performed a review...
The incidental discovery of focal liver lesions (FLLs) has reached unprecedented levels due to the widespread use of high-resolution imaging, yet unenhanced ultrasound often lacks the specificity required for definitive characterization. This review...
Background/Objectives: Progressive familial intrahepatic cholestasis type 1 (PFIC1) is a rare autosomal recessive liver disorder caused by mutations in the ATP8B1 gene, leading to defective bile acid secretion and severe clinical outcomes. A milder,...
Background: Alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II (PIVKA-Il) are established biomarkers for hepatocellular carcinoma (HCC). The ASAP score, incorporating age, sex, AFP, and PIVKA-II, may improve diagnosis, but data from...
Background: Non-alcoholic fatty liver disease (NAFLD), now largely encompassed by the metabolic dysfunction-associated steatotic liver disease (MASLD) framework, is a leading cause of chronic liver disease worldwide and is closely linked to obesity,...
As metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD) grow increasingly prevalent, it is essential to improve understanding of the contributing factors and how these conditions may interact. Me...
Introduction: Hepatitis B virus (HBV) genotypes exhibit distinct geographic distributions and may differ in virological expression. In low-endemic settings such as Canada, where chronic HBV burden is largely migration-driven, clinical cohorts provide...
Background/Objectives: Hexavalent chromium [Cr(VI)] is a toxic metal that enters the environment due to natural and anthropogenic processes. The liver is a major target organ of Cr(VI) exposure through drinking water, resulting in an increased risk o...
Metabolic dysfunction-associated steatohepatitis (MASH) represents a systems-level disorder driven by the interplay of metabolic stress, bile acid dysregulation, gut microbiota remodeling, and immune activation. Because no single experimental platfor...
Background/Objectives: Post-hepatectomy biliary leakage (BL) remains a major source of postoperative morbidity. While traditional risk models treat BL as a single clinical entity, its chronological presentation follows distinct patterns that raise th...
Liver fibrosis is the common pathway through which chronic liver injury progresses to cirrhosis, portal hypertension, liver failure, hepatocellular carcinoma, and systemic complications. Its burden is increasing worldwide, driven mainly by metabolic...
Hepatic ischemia–reperfusion injury (IRI) is a major clinical challenge in liver surgery and transplantation, contributing to postoperative complications and graft dysfunction. The pathogenesis of hepatic IRI is complex and multifactorial, invo...
Background/Objectives: Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide, due to poor prognosis and limited curative options in advanced stages. Though immune checkpoint inhibitor (ICI)-based combinations have been...
Aggressive systemic mastocytosis [ASM] is a rare hematologic disorder characterized by mast cell infiltration of extracutaneous organs. Hepatic involvement is uncommon and rarely progresses to fibrosis or portal hypertension. We present a 60-year-old...
Background/Objectives: Hypothermic oxygenated perfusion (HOPE) improves graft preservation in whole liver transplantation, yet evidence supporting its use in split grafts for pediatric transplantation remains limited. Mitochondrial injury assessed du...
Geranylgeranoic acid (GGA) is an endogenous acyclic diterpenoid metabolite of the mevalonate pathway that has been implicated in programmed cell death in hepatoma cells and may contribute to the elimination of premalignant hepatocytes. Recent metabol...
