Primary Intraosseous Squamous Cell Carcinoma of the Anterior Mandible Arising in an Odontogenic Cyst in 34-Year-Old Male
, Massimo Pinelli 5, Luigi Chiarini 6,† and Alexandre Anesi 6,*,†
Round 1
Reviewer 1 Report
"PRIMARY INTRAOSSEOUS SQUAMOUS CELL CARCINOMA OF THE ANTERIOR MANDIBLE ARISING IN AN ODONTOGENIC CYST IN 34-YEAR-OLD MALE" is a case report about the occurrence of a squamous cell carcinoma in a pre-existent mandibular cyst. The topic is interesting because the patology is exceeding rare and the best therapy is matter of debate. The manuscript is well written and the discussion is well developed.
I have to make only one observation: the manuiscript is devoid of histological pictures. The diagnosis of primary squamous cell carcinoma of the mandibula is not easy and there are many confounders, including pseudoepitheliomatous changes of the squamous epithelium lining mandibular cysts. So, the Authors should include the histological pictures, demonstrating the diagnosis of squamous cell carcinoma, the infiltration of the bone tissue and possibly the infiltration of the extraosseous soft tissues.
Author Response
We are agree with Reviewer 1. We provide 2 composite histological pictures: the former (figure 5) following the diagnostic biopsy, the latter (figure 10) following the surgical sample with bone/connective tissue invasion.
Reviewer 2 Report
The case report entitled “Primary intraosseous squamous cell carcinoma of the anterior mandible arising in an odontogenic cyst in a 34-year-old male” is a nice and well-written piece of work reporting a case of primary intraosseous squamous cell carcinoma (PIOSCC), a rare and aggressive malignancy with unknown aetiology, in a young man.
The reported clinical data are accurate and complete and clearly synthesized in Table 2. The amount of photographic and radiographic details is remarkable and also the presence of videos makes this case very well documented. Moreover, the authors reviewed the literature reporting changes in the definition and classification of the PIOSCC over the years.
The results are interesting, showing that the patients treated with the aid of adjuvant therapy had a good local control and quality of life.
Overall, I think the paper is interesting. However, I suggest only minor grammar and language corrections (e.g. use extended forms “has not” and “it is” instead of contracted forms “hasn’t” and “it’s”).
Author Response
We are agree with Reviewer 2 observation. We used the extended verbal forms rahter then the contracted one.
