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High-Throughput 2017, 6(3), 12; doi:10.3390/ht6030012

High‐Throughput Methods to Detect Long Non‐Coding RNAs

Cardiovascular Innovation Institute, University of Louisville, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Academic Editor: Massimo Negrini
Received: 21 August 2017 / Accepted: 29 August 2017 / Published: 31 August 2017
View Full-Text   |   Download PDF [165 KB, uploaded 1 September 2017]

Abstract

Increasing evidence suggests that the numbers of long non‐coding RNAs (lncRNAs) are more than those of protein‐coding genes in various organisms. Although the detection methods for lncRNAs are being increasingly established, there are advantages and disadvantages that exist for each method. In this opinion article, I highlight the differences between microarrays and RNA sequencing (RNA‐seq) for the detection of lncRNAs. Compared to RNA‐seq, microarrays are limited to the known sequences. However, the detection method as well as data analysis workflow is more established, which makes it easier to analyze the data for bench scientists without extensive knowledge about computer programming. In order to highlight the usage of microarrays over RNA‐seq for the detection of lncRNAs, we are organizing a special issue for High‐Throughput called “Microarrays in Non‐Coding RNAs Profiling”, which will include the specific usages of microarrays for lncRNAs. View Full-Text
Keywords: long non‐coding RNA; non‐coding RNA; microarray; RNA‐seq long non‐coding RNA; non‐coding RNA; microarray; RNA‐seq
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Uchida, S. High‐Throughput Methods to Detect Long Non‐Coding RNAs. High-Throughput 2017, 6, 12.

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