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Proceedings 2017, 1(6), 655; doi:10.3390/proceedings1060655 (registering DOI)

Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies

1
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid (CEI Campus Moncloa UCM-UPM and CSIC), Pza. Ramón y Cajal s/n, 28040 Madrid, Spain
2
Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900 Rio de Janeiro, Brazil
3
Instituto de Química Médica (IQM), CSIC, Calle Juan de la Cierva 3, 28006 Madrid, Spain
Presented at the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain, 8 September 2017.
*
Author to whom correspondence should be addressed.
Published: 17 October 2017
(This article belongs to the Proceedings of the 1st Molecules Medicinal Chemistry Symposium)
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Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas disease, show limited effectiveness and high toxicity that prompt the identification of therapeutic alternatives. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fonseca-Berzal, C.; Silva, C.F.; Batista, M.M.; Guedes-da-Silva, F.H.; Vasconcelos, M.; Demarque, K.C.; Escario, J.A.; Arán, V.J.; Soeiro, M.N.C.; Gómez-Barrio, A. Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies. Proceedings 2017, 1, 655.

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