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Proceedings 2017, 1(4), 526; doi:10.3390/proceedings1040526

Modelling and Characterisation of Droplet Generation and Trapping in Cell Analytical Two-Phase Microfluidic System

1
Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary
2
Institute of Technical Physics and Materials Science, Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 25 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
Download PDF [1917 KB, uploaded 26 August 2017]

Abstract

Present study analyses the influence of flow characteristics of special water-oil two-phase microfluidic systems regarding the droplet generation, cell encapsulation and trapping processes. Water droplets were dispersed in oil continuous phase with the requirement of precise size distribution to enable effective cell entrapment. The evolving droplet size and the number of encapsulated cells were examined considering the applied flow rate ratios of the two phases. The hydrodynamic behaviour of the microfluidic system was modelled by Finite Element Method (FEM) coupled with particle trajectory calculation applying COMSOL Multiphysics code. The experimental results were compared to the simulation and the applicability of our droplet based cell encapsulating and trapping microfluidic system was characterised.
Keywords: droplet generation; cell entrapment; two-phase flow microfluidics; impedance analysis droplet generation; cell entrapment; two-phase flow microfluidics; impedance analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tóth, A.B.; Holczer, E.; Hakkel, O.; Tóth, E.L.; Iván, K.; Fürjes, P. Modelling and Characterisation of Droplet Generation and Trapping in Cell Analytical Two-Phase Microfluidic System. Proceedings 2017, 1, 526.

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