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Proceedings 2017, 1(4), 513; doi:10.3390/proceedings1040513

Integrated System Based on Thin Film Technologies for Cell-Based Bioluminescence Assays

1
Department of Information Engineering, Electronics and Telecommunications, Sapienza University of Rome, Rome, Italy
2
School of Aerospace Engineering, Sapienza University of Rome, Rome, Italy
3
Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna, Bologna, Italy
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 16 August 2017
Download PDF [642 KB, uploaded 16 August 2017]

Abstract

This work presents a miniaturized lab-on-chip system suitable for monitoring the activity of living cells through the on-chip detection of their bioluminescence emission. The system integrates amorphous silicon diodes, acting as temperature and light sensors, and indium tin oxide film, acting as heater, on a single glass substrate. During its operation, the glass is thermally and optically coupled to the investigated cells and electrically connected to an electronic board, which controls the lab-on-chip temperature and monitors the sensor photocurrents. The proposed lab-on-chip is particularly attractive for the development of portable cell-based biosensors useful for biological activity monitoring as well as for cell cytotoxicity evaluation.
Keywords: lab-on-chip; thin film technology; amorphous silicon; bioluminescence; cell bioreporter lab-on-chip; thin film technology; amorphous silicon; bioluminescence; cell bioreporter
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Caputo, D.; Petrucci, G.; Fiore, V.D.; Buzzin, A.; Nardecchia, M.; Cevenini, L.; Michelini, E.; Mirasoli, M.; Roda, A.; Lovecchio, N.; Costantini, F.; Nascetti, A.; Cesare, G. Integrated System Based on Thin Film Technologies for Cell-Based Bioluminescence Assays. Proceedings 2017, 1, 513.

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