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Proceedings 2017, 1(4), 502; doi:10.3390/proceedings1040502

Multiphysics Probe for Deep Brain Monitoring of Glioblastoma Environment

1
Institut des Nanotechnologies de Lyon, Villeurbanne, France
2
Centre de Recherche en Neurosciences de Lyon, Lyon, France
3
Laboratoire Hubert Curien, Saint-Etienne, France
4
Laboratoire Ampère, Villeurbanne, France
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Author to whom correspondence should be addressed.
Published: 17 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
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Abstract

This work reports on the development, and preliminary results of a multiphysics probe for deep brain monitoring of neurotransmitters and metabolites in the glioblastoma environment. We made the proof of the concept of our probe with common mice glioblastoma cells GL261 modified with Green Fluorescent Protein. A silicon probe with a platinum electrode at the tip was functionalized with an enzyme in order to detect, for example, Glucose, D-serine, Lactate or Glutamate. In addition, an optical fiber was inserted in a groove in the middle of the probe for light excitation and detection of glioblastoma cells by fluorescence.
Keywords: deep brain monitoring; enzymatic biosensor; fluorescent biosensor; glioblastoma; bioMEMS; microfabrication deep brain monitoring; enzymatic biosensor; fluorescent biosensor; glioblastoma; bioMEMS; microfabrication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chatard, C.; Pascual, O.; Jourlin, Y.; Marinesco, S.; Barbier, D.; Sabac, A. Multiphysics Probe for Deep Brain Monitoring of Glioblastoma Environment. Proceedings 2017, 1, 502.

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