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Proceedings 2017, 1(4), 497; doi:10.3390/proceedings1040497

A Tubing-Free, Microfluidic Platform for the Realization of Physiologically Relevant Dosing Curves on Cellular Models

1
ETH Zurich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland
2
InSphero AG, 8952 Schlieren, Switzerland
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
*
Authors to whom correspondence should be addressed.
Published: 5 September 2017
Download PDF [1087 KB, uploaded 5 September 2017]

Abstract

We present a microfluidic tilting platform with gravity-driven flow that enables culturing of three-dimensional microtissues under in vivo-like drug dosing regimens. In contrast to traditional, constant dosing regimens, the chip allows for gradual changes in substance concentrations. Dosing gradients are generated through an asymmetric Y-junction of microfluidic channels of different widths. Changes in the chip operation parameters, e.g., different tilting angles, enable to alter the drug dosage on demand. The concentration changes over time matched the predicted values, and preformed microtissues could be cultured in the chip system for at least 24 h. The chip represents an easy-to-handle tool for toxicity and efficacy testing of transient drug concentrations changes.
Keywords: microfluidics; tilting chip; pharmacokinetics; 3D microtissues microfluidics; tilting chip; pharmacokinetics; 3D microtissues
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lohasz, C.; Frey, O.; Renggli, K.; Hierlemann, A. A Tubing-Free, Microfluidic Platform for the Realization of Physiologically Relevant Dosing Curves on Cellular Models. Proceedings 2017, 1, 497.

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