DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing†
AbstractWe report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces.
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Gállego, I.; Manning, B.; Prades, J.D.; Mir, M.; Samitier, J.; Eritja, R. DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing. Proceedings 2017, 1, 325.
Gállego I, Manning B, Prades JD, Mir M, Samitier J, Eritja R. DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing. Proceedings. 2017; 1(4):325.Chicago/Turabian Style
Gállego, Isaac; Manning, Brendan; Prades, Joan Daniel; Mir, Mònica; Samitier, Josep; Eritja, Ramon. 2017. "DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing." Proceedings 1, no. 4: 325.
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