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Proceedings 2017, 1(4), 278; doi:10.3390/proceedings1040278

Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems

Electronics and Computer Science, University of Southampton, Southampton, UK
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
Author to whom correspondence should be addressed.
Published: 16 August 2017
(This article belongs to the Proceedings of Eurosensors 2017)
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The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications.
Keywords: capillary electrophoresis; microfluidic modelling; separation enhancement capillary electrophoresis; microfluidic modelling; separation enhancement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lewis, A.; Harris, N. Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems. Proceedings 2017, 1, 278.

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