Next Article in Journal
Turkish Medicinal Plants Used in Cancer Treatment and Evaluation of Plant Usage in the Oncology Clinic of the İstanbul University Faculty of Medicine
Previous Article in Journal
A Study of Gender Advertisements. A Statistical Measuring of the Prevalence of Genders’ Patterns in the Images of Print Advertisements
Article Menu

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 984; doi:10.3390/proceedings1100984

Synergistic Cytotoxic Effects of Resveratrol in Combination with Ceramide Metabolizing Enzymes in Ph + Acute Lymphoblastic Leukemia

Molecular Biology and Genetics, Faculty of Life and Natural Sciences, Abdullah Gul University, Kayseri 38080, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 16 November 2017
Download PDF [133 KB, uploaded 16 November 2017]

Abstract

Bioactive sphingolipids are a lipid family including ceramide, sphingosine-1-phosphate (S1P) and glucosyl ceramide (GC). Ceramide produced through de novo synthesis pathway (Serine Palmitoyl Transferase (SPT) is a key enzyme subjected to regulation) plays significant roles in the induction of apoptosis. On the other hand, the conversion of ceramide into S1P and GC by sphingosine kinase 1 (SK-1) and glucosyl ceramide synthase (GCS) induce the proliferation of cancer cells. It is aimed to investigate therapeutic potential of resveratrol on Ph + ALL cells and to identify potential mechanisms behind resveratrol-mediated cytotoxicity in association with targeting of ceramide metabolism. The antiproliferative effects of resveratrol, SPT inhibitor (myriocin), SK-1 inhibitor (SKI II), GCS inhibitor (PDMP), resveratrol: SPT inhibitor, resveratrol: SK-1 inhibitor and resveratrol:GCS inhibitor combinations on SD-1 cells are investigated by cell proliferation assay. The combination indexes are calculated using Calcusyn program. There were synergistic cytotoxic effects of resveratrol with co-administration of myriocin, SK-1 inhibitor and GCS inhibitor. This preliminary data showed for the first time that resveratrol might inhibit the growth of Ph + ALL cells through targeting ceramide metabolism. Molecular studies are still undergoing to reveal the mechanisms behind this synergistic effects.
Keywords: Ph + ALL; resveratrol; ceramide; serine palmitoyl transferase; sphingosine kinase 1 Ph + ALL; resveratrol; ceramide; serine palmitoyl transferase; sphingosine kinase 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Oğuz, O.; Adan, A. Synergistic Cytotoxic Effects of Resveratrol in Combination with Ceramide Metabolizing Enzymes in Ph + Acute Lymphoblastic Leukemia. Proceedings 2017, 1, 984.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top