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Proceedings 2017, 1(10), 977; doi:10.3390/proceedings1100977

Ins and Outs of Flavonoids in Cancer Prevention vs. Cancer Therapy: A Lesson from Quercetin in Leukemia

Institute of Food Sciences, National Research Council, Avellino 83100, Italy
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
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Published: 13 November 2017
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Abstract

We recently critically reviewed clinical and pre-clinical studies on the concept that polyphenols, being antioxidant compounds, can fight cancer. We suggest that a clear distinction must be done between the use of polyphenols, such as flavonoids, in cancer treatment versus cancer prevention, starting from adequate and specifically selected cellular models. As an example, we will present data on the potential application of quercetin against chronic lymphocytic leukemia (CLL). Previous studies from our group indicated that quercetin synergistically sensitizes to apoptosis several leukemic cell lines and B-cells isolated from CLL patients, when associated with other pro-apoptotic agents. Using HG3 cells, derived from primary B-cells immortalized with Epstein-Barr virus, we demonstrated that the association between ABT-737, a BH3-mimetics, and quercetin synergistically induces apoptosis through the inhibition of PI3K/Akt signaling pathway. More importantly, we identified the protein kinase CK2 as a new, direct and primary target of quercetin, since CK2 activity was inhibited by the flavonoid within one minute from the treatment. Considering the rapid uptake of quercetin and its low toxicity against normal peripheral blood cells, we recommend the design of clinical studies aimed to demonstrate the potential use of the molecule in the adjuvant chemotherapy against CLL.
Keywords: quercetin; chemoprevention; chronic lymphocytic leukemia; antioxidants quercetin; chemoprevention; chronic lymphocytic leukemia; antioxidants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Russo, G.L.R.; usso, M.; Spagnuolo, C.; Moccia, S. Ins and Outs of Flavonoids in Cancer Prevention vs. Cancer Therapy: A Lesson from Quercetin in Leukemia. Proceedings 2017, 1, 977.

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