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Proceedings 2017, 1(10), 974; doi:10.3390/proceedings1100974

Cynaropicrin:A Promising Natural Agent with Antitumor and Antiviral Activities

1
Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
2
Pharmacology and Toxicology Unit, Institute of Biomedicne, University of Oulu, Oulu 90014, Finland
3
Nice 06100, France
4
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08002, Spain
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 17 November 2017
Download PDF [151 KB, uploaded 29 November 2017]

Abstract

Most natural agents do not induce a high level of toxicity and target multiple signaling pathways involved in cell growth, invasion, apoptosis, angiogenesis and metastasis. Human infection with HCV is currently recognized as the leading cause of hepatocellular carcinoma (HCC) which demands liver transplantation which was estimated to result in ∼10,000 deaths in the US only in the year 2011. Cynaropicrin is a potential agent for treatment and prevention of HCC by indirect way through inhibition of HCV and in a direct way evidenced by the many antitumor activities in literature. Additionally, cynaropicrin has anti-inflammatory, TNF-α inhibitory, and antioxidant activities and hence it can also prevent the progression of HCC. The compounds cynaropicrin and grosheimol, obtained from the wild Egyptian artichoke (Cynara cardunculus L. var. sylvestris), showed EC50 at 1.03 μM, and 1.27 μM, by using a luciferase-carrying reporter virus. Time-of-addition experiments revealed that cynaropicrin and grosheimol inhibited HCV virus at a time-point during entry. Finally, the results showed that these compounds inhibited HCV particles from genotypes 1a, 1b, 2b, 3a, 4a, 5a, 6a and 7a indicating that these compounds inhibit HCV cell entry independently of viral genotype or subtype. In conclusion, cynaropicrin is a very promising drug as antitumor agent.
Keywords: cynaropicrin; grosheimol; HCC; HCV; the wild Egyptian artichoke cynaropicrin; grosheimol; HCC; HCV; the wild Egyptian artichoke
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Elsebai, M.F.; Hakkola, J.; Mehiri, M.; Diez, J. Cynaropicrin:A Promising Natural Agent with Antitumor and Antiviral Activities. Proceedings 2017, 1, 974.

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