Next Article in Journal
Biologically Transformed Propolis Exhibits Cytotoxic Effect on A375 Malignant Melanoma Cells In Vitro
Previous Article in Journal
Comparative Evaluation of the Cytotoxic Effects of Stem and Flower Extracts of Rhaponticoides iconiensis (Hub.-Mor.) M.V.Agab. & Greuter
Article Menu
Issue 10 (NPCPT 2017) cover image

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 1066; doi:10.3390/proceedings1101066

Ameliorative Effects of Carvacrol on Cyclophosphamide-Induced Testis Damage and Oxidative Stress

Department of Mathematics and Science Education, Education Faculty, Siirt University, Siirt 56100, Turkey
Biology Department, Art and Science Faculty, Eskişehir Osmangazi University, Eskişehir 26040, Turkey
Vocational School of Health Services, Eskişehir Osmangazi University, Eskişehir 26040, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [137 KB, uploaded 27 February 2018]


Cyclophosphamide (CP) is an effective drug widely used for treating clinical cancer and non-malignant diseases. However, using CP causes cytotoxicity in one or more tissues. The present study aims to investigate possible protective effects of Carvacrol (Cr), which is an essential component of thyme and also known for its antioxidant properties, upon testis toxicity. For this study, 35 male rats were categorized into 5 groups, each of them including 7 members. Blood samples and testis tissues were obtained from each animal for the evaluation of biochemical markers and histopathological examination. Assessment of serum and testis sampled revealed that Cr has a significant role in protecting against CP-caused testis damage. Our data also show that Cr is a very effective antioxidant with cell-protecting properties. For this reason, we conclude that Cr could help reduce the side-effects of anticancer drugs as far as chemotherapy protocols are concerned.
Keywords: Cyclophosphamide; Carvacrol; Testes Damage; Antioxidant; Oxidative Stress Cyclophosphamide; Carvacrol; Testes Damage; Antioxidant; Oxidative Stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cengiz, M.; Teksoy, O.; Sahinturk, V.; Tekin, Y.; Gunes, S.; Ayhanci, A. Ameliorative Effects of Carvacrol on Cyclophosphamide-Induced Testis Damage and Oxidative Stress. Proceedings 2017, 1, 1066.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top