The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line†
AbstractTocopherols, the major forms of vitamin E, are a family of fat-soluble phenolic compounds. Each tocopherol contains a chromanol ring system and a phytyl chain containing 16 carbons. Tocopherols, as effective antioxidants, have been proposed to protect against carcinogenesis. Colon carsinoma cell line were treated with tocopherol-α (0, 3.12, 6.25, 12.5, 25, 50, 100, 200 uM). Cell viability and migration were examined. Cell viability was determined MTT assay and cell migration was determined by wound healing assay. Caco-2 cells were treated with for 24 h, 48 h and 72 h incubation. There is a significant decrease was observed at 50, 100 and 200 µM for 48 h and 72 h incubation on cell viability in the MTT assay. Wound healing method observed decrease on migration at 12, 5, 25 and 50 µM in 24 h. These results suggest that tocopherol-α have promising antiproliferative effect on cell viability for research on cancer.
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Gök, A.; Kurtdede, E.; Cengiz, R.S.; Kısmalı, G.; Sel, T. The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line. Proceedings 2017, 1, 1062.
Gök A, Kurtdede E, Cengiz RS, Kısmalı G, Sel T. The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line. Proceedings. 2017; 1(10):1062.Chicago/Turabian Style
Gök, Ayşenur; Kurtdede, Efe; Cengiz, Remzi Soner; Kısmalı, Görkem; Sel, Tevhide. 2017. "The Effect of Tocopherol-α on the Cell Viability in Caco-2 Cell Line." Proceedings 1, no. 10: 1062.