The Effects of Benzoxasol Derivate Compounds in Breast Cancer Cells†
AbstractBreast cancer today is the most frequent cancer among women, and the second most common cause of cancer deaths among women. The aim of this study was to synthesize a new benzoxazole derivative, scan it for anti-cancer potential by MTT test using different breast cancer cell lines, and examine its effects on NF-κB and apoptosis related proteins by the western blot method. A newly synthesized benzoxazole derived compound was applied to cancer cell lines and its cytotoxicity was measured quantitatively by MTT test. Later, the level of its effects on NF-κB and apoptosis related proteins were examined. The structure of the compound synthesized in our study (5-amino-2-(p-bromobenzyl) benzoxazoleand 5-[4-chlorobutanamido]-2-(p-methylphenyl) benzoxazole were proved by elemental analysis. In the assay of the proteins by western, when heterocyclic compounds were added to the MDA and MCF-7 cell line, there was no difference from the control group in Apaf-1 and BCL-2 levels, but a reduction was observed in caspase and Nfkβ levels compared with the control group. It is seen that this newly synthesized heterocyclic compound increases apoptosis by reducing the activation of Nfkβ, and in this way has shown an effect of inhibiting tumor growth in cancer treatment.
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Kosova, F.; Temiz-Arpacı, Ö.; Ölmez, E.; Tuğlu, İ. The Effects of Benzoxasol Derivate Compounds in Breast Cancer Cells. Proceedings 2017, 1, 1046.
Kosova F, Temiz-Arpacı Ö, Ölmez E, Tuğlu İ. The Effects of Benzoxasol Derivate Compounds in Breast Cancer Cells. Proceedings. 2017; 1(10):1046.Chicago/Turabian Style
Kosova, Funda; Temiz-Arpacı, Özlem; Ölmez, Ercüment; Tuğlu, İbrahim. 2017. "The Effects of Benzoxasol Derivate Compounds in Breast Cancer Cells." Proceedings 1, no. 10: 1046.
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