Next Article in Journal
Determination of Antioxidant Capacity, Phenolic Acid Composition and Antiproliferative Effect Associated with Phenylalanine Ammonia Lyase (PAL) Activity in Some Plants Naturally Growing under Salt Stress
Previous Article in Journal
Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor
Article Menu

Article Versions

Export Article

Open AccessAbstract
Proceedings 2017, 1(10), 1026; doi:10.3390/proceedings1101026

The Neurotoxic Effects of Origanum minutiflorum

1
Department of Medicinal Biochemistry, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
2
Department of Medicinal Biology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
3
Department of Medicinal Microbiology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
4
, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
5
Department of Medicinal Pharmacology, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
6
Department of Arts and Sciences, Faculty of Medicine, Niğde Ömer Halisdemir University, Niğde 51000, Turkey
7
Department of Medicinal Pharmacology, Faculty of Medicine, Manisa Celal Bayar University, Manisa 45000, Turkey
8
Department of Histology and Embryology, Faculty of Medicine, Manisa Celal Bayar University, Manisa 45000, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 10 November 2017
Download PDF [166 KB, uploaded 13 November 2017]

Abstract

The natural products are promising products for anti-proliferative effects in cancer. In this study our aim was to analyze the neurotoxic effect of Origanum minutiflorum O. Schwarz & PH. Davis on neuroblastoma cells in in vitro conditions. The neuroblastoma cells were treated with Oregano oil from Origanum minutiflorum and doxorubicin, and cytotoxic activities of these agents were evaluated by MTT assay for IC50 doses. The immunocytochemistry staining of eNOS, iNOS and TUNEL assay were performed. The results were analyzed using Graphpad software for one-way-ANOVA. The immunoreactivities of eNOS and iNOS were increased in neuroblastoma cells treated with oregano oil and doxorubicin. Both of Oregano oil and doxorubicin showed inhibitory activity against neuroblastoma cells via oxidative stress. Also the number of apoptotic cells was greater than the control group. The oregano oil enhanced the cytotoxic activity of doxorubicin. The compound of oregano oil should be considered with the other neuroblastoma cells for neurotoxicity.
Keywords: Neuroblastoma; Origanum minutiflorum; neurotoxicity; oxidative stress; apoptosis Neuroblastoma; Origanum minutiflorum; neurotoxicity; oxidative stress; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sari, İ.; Dönmez, G.; Kırık, F.E.; Aydemir, I.; Özkan, O.; Savran, A.; Vural, K.; Tuğlu, M.İ. The Neurotoxic Effects of Origanum minutiflorum. Proceedings 2017, 1, 1026.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top