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Proceedings 2017, 1(10), 1007; doi:10.3390/proceedings1101007

Development of Effective Anticancer Drug Candidates against Breast and Colon Cancers

1
Department of Chemistry, Faculty of Sciences, Erciyes University, Kayseri 38039, Turkey
2
Faculty of Pharmacy, The University of Sydney, Sydney 2006, Australia
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [129 KB, uploaded 15 November 2017]

Abstract

Breast and colon cancers are a global health problem and they are responsible for causing a large number of deaths. Both of them rank among the most dangerous types of cancer. DLD-1, MDA-MB-231 and HEK 293T cells were cultured in DMEM medium supplemented with 10% FBS. The cells were seeded into sterile 96-well plates at a density of 1 × 103 cells/well. Cancerous cells were exposed to synthesized drug candidates at nine different concentrations for 72 h. The normal human cells were exposed to drug candidates in the 0.001–100 µM range for 24 h. All the synthesized compounds showed evidence of enhanced cytotoxic activity against tested cell lines. In general, compounds containing aromatic groups showed more cytotoxic activity compared to compounds containing alkyl groups. Furthermore, a few compounds showed roughly more in vitro cytotoxic activity than the well-known chemotherapeutic agent cisplatin. A lot of new compounds as NHC precursors were synthesized and extensively characterized. The anticancer properties of compounds were tested. Our results demonstrate that a few compounds exhibited promising results against cancerous cell lines that can be warranted for further investigation as a potential anticancer agent.
Keywords: Benzimidazolium salt; cytotoxic activity; breast cancer; colon cancer; MDA-MB-231; DLD-1; HEK-293T; IncuCyte; confocal image Benzimidazolium salt; cytotoxic activity; breast cancer; colon cancer; MDA-MB-231; DLD-1; HEK-293T; IncuCyte; confocal image
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Akkoç, S.; İlhan, İ.Ö.; Kayser, V. Development of Effective Anticancer Drug Candidates against Breast and Colon Cancers. Proceedings 2017, 1, 1007.

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