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Trop. Med. Infect. Dis. 2017, 2(2), 5; doi:10.3390/tropicalmed2020005

Four Thousand Years of Concepts Relating to Rabies in Animals and Humans, Its Prevention and Its Cure

1
Epidemiology & Public Health Unit, Institut Pasteur du Cambodge, BP983 Phnom Penh, Cambodia
2
Unité de Recherche et d’Expertise en Maladies Infectieuses (UREMI), Institut Pasteur de Nouvelle-Calédonie, 9800 Nouméa, New Caledonia
Academic Editors: Charles Rupprecht and Bernhard Dietzschold
Received: 20 February 2017 / Revised: 16 March 2017 / Accepted: 17 March 2017 / Published: 24 March 2017
(This article belongs to the Special Issue Rabies Symptoms, Diagnosis, Prophylaxis and Treatment)
View Full-Text   |   Download PDF [6249 KB, uploaded 28 March 2017]   |  

Abstract

The epitome of the One Health paradigm—and of its shortcomings—rabies has been known to humankind for at least 4000 years. We review the evolution through history of concepts leading to our current understanding of rabies in dogs and humans and its prevention, as transmitted by accessible and surviving written texts. The tools and concepts currently available to control rabies were developed at the end of the 19th Century, including the first live, attenuated vaccine ever developed for humans and the first post-exposure prophylaxis (PEP) regimen. No progress, however, has been made in etiological treatment, leaving clinicians who provide care to animals or patients with symptomatic rabies as powerless today as their colleagues in Mesopotamia, 40 centuries ago. Rabies remains to date the most lethal infectious disease known to humans. Widespread access to timely, effective, and affordable PEP in rural areas of developing countries is urgently needed. View Full-Text
Keywords: rabies; vaccine; history; One Health; post-exposure prophylaxis; Galtier; Roux; Pasteur; Semple; dog rabies; vaccine; history; One Health; post-exposure prophylaxis; Galtier; Roux; Pasteur; Semple; dog
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tarantola, A. Four Thousand Years of Concepts Relating to Rabies in Animals and Humans, Its Prevention and Its Cure. Trop. Med. Infect. Dis. 2017, 2, 5.

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