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J. Funct. Morphol. Kinesiol. 2018, 3(1), 12; https://doi.org/10.3390/jfmk3010012

PKC Proteins and Muscular Dystrophy

1
Sport and Exercise Medicine Centre (SEM), Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
2
Unit Biomedical, Biotechnological and Translational Sciences (SBiBiT), Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
3
Anatomy and Histology Section, Department of Morphology and Experimental Medicine and Surgery, University of Ferrara, 44121 Ferrara, Italy
*
Author to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 30 January 2018 / Accepted: 5 February 2018 / Published: 7 February 2018
(This article belongs to the Special Issue Muscular Dystrophy)
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Abstract

Protein Kinase Cs (PKCs) are a family of 10 isoenzymes with critical roles in cell physiological processes like proliferation, differentiation, apoptosis. Muscular dystrophies are a heterogenous group of genetic degenerative diseases that affect skeletal and cardiac muscles. In the development of muscular dystrophies, several transduction pathways have been studied. A possible link between muscular dystrophies and PKCs have been recently proposed. After a brief description of the possible transduction pathways that are involved in the development of these genetic diseases, we summarize recent evidence on the role of PKC proteins in muscular dystrophies, with the aim to review possible candidates in molecular therapy of these pathologies. View Full-Text
Keywords: PKCs; muscular dystrophies; cell signaling pathways PKCs; muscular dystrophies; cell signaling pathways
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Gobbi, G.; Galli, D.; Carubbi, C.; Neri, L.M.; Masselli, E.; Pozzi, G.; Vitale, M.; Mirandola, P. PKC Proteins and Muscular Dystrophy. J. Funct. Morphol. Kinesiol. 2018, 3, 12.

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J. Funct. Morphol. Kinesiol. EISSN 2411-5142 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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