Next Article in Journal
Progress for Journal of Functional Morphology and Kinesiology in 2016
Next Article in Special Issue
Effects of Stochastic Resonance on Sensorimotor Performance during Exercise-Induced Muscle Damage
Previous Article in Journal
The Duality of Knee Functional Axes and Foot Contact
Article Menu

Export Article

Open AccessArticle
J. Funct. Morphol. Kinesiol. 2016, 1(4), 396-406; doi:10.3390/jfmk1040396

Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study

Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53705, USA
School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53705, USA
Author to whom correspondence should be addressed.
Academic Editors: Giuseppe Musumeci and Marta Anna Szychlinska
Received: 24 October 2016 / Revised: 1 December 2016 / Accepted: 8 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Muscle Damage and Regeneration)
View Full-Text   |   Download PDF [1206 KB, uploaded 15 December 2016]   |  


Stem cells have shown promise as a therapeutic intervention by enhancing skeletal muscle regeneration following muscle injury. The purpose of this study was to determine the effect of mouse mesenchymal stem cells (MSCs) on muscle function following a single stretch injury in the calf muscle of C57BL/67 mice. A custom isokinetic device was used to induce a single stretch injury. An intramuscular injection of MSCs or saline was administered three days post-injury. Mechanical testing to measure peak isometric joint torque in vivo was done immediately and at seven or 14 days post-injury. Susceptibility to reinjury was assessed in the soleus muscle using an in situ repeated eccentric contraction (ECC) protocol. In vivo isometric torque of the plantar flexors dropped immediately following stretch injury by 50%. Treatment with MSCs attenuated the torque deficit at seven days, while there were no differences in torque deficit between groups at 14 days. In situ ECC testing of the soleus showed a significant specific force drop following injury, with the MSC group demonstrating a protective effect at seven and 14 days. These results demonstrate transient improvement in isometric torque and reduced susceptibility to reinjury following single stretch injury with intramuscular injection of MSCs. View Full-Text
Keywords: muscle strain; stem cells; healing; mechanical testing; mouse muscle strain; stem cells; healing; mechanical testing; mouse

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Brickson, S.; Meyer, P.; Saether, E.; Vanderby, R. Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study. J. Funct. Morphol. Kinesiol. 2016, 1, 396-406.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
J. Funct. Morphol. Kinesiol. EISSN 2411-5142 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top