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J. Funct. Morphol. Kinesiol. 2016, 1(1), 140-153; doi:10.3390/jfmk1010140

The Genetics of Osteoarthritis: A Review

1
Academic Rheumatology, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
2
Arthritis Research UK Pain Centre, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Musumeci
Received: 1 February 2016 / Revised: 26 February 2016 / Accepted: 4 March 2016 / Published: 10 March 2016
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Abstract

Osteoarthritis (OA) is the most common form of arthritis and is a leading cause of pain and disability worldwide. There is thought to be an important genetic component to the development of OA. In this review article, the methods used to study the genetics of OA are discussed, along with the main findings from these analyses, with a particular focus on the results of genome-wide association scans (GWAS). Functional validation of the results from genetic studies of OA is also described to put the genetic results into a biological context and show their relevance to the mechanisms involved in the development and progression of OA. The clinical relevance of the genetic findings to date is also discussed, as well as the research, which is still needed in this field to further improve the understanding of OA pathogenesis. View Full-Text
Keywords: genetics; osteoarthritis; genome-wide association scan; pain genetics; osteoarthritis; genome-wide association scan; pain
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Warner, S.C.; Valdes, A.M. The Genetics of Osteoarthritis: A Review. J. Funct. Morphol. Kinesiol. 2016, 1, 140-153.

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J. Funct. Morphol. Kinesiol. EISSN 2411-5142 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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