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Int. J. Neonatal Screen. 2017, 3(2), 7; https://doi.org/10.3390/ijns3020007

Impact of Lower Screening TSH Cutoff Level on the Increasing Prevalence of Congenital Hypothyroidism

1
Laboratory for Neonatal Thyroid Screening, University Pediatric Clinic, Medical Faculty, Skopje 1000, Macedonia
2
Department of Endocrinology and Genetics, University Pediatric Clinic, Medical Faculty, Skopje 1000, Macedonia
*
Author to whom correspondence should be addressed.
Academic Editor: Harvey Levy
Received: 7 February 2017 / Revised: 24 March 2017 / Accepted: 30 March 2017 / Published: 4 April 2017
(This article belongs to the Special Issue Newborn Screening-Past, Present and Future)
View Full-Text   |   Download PDF [175 KB, uploaded 7 April 2017]

Abstract

Lower cutoff levels in screening programs have led to an increase in the proportion of detected cases of transient hypothyroidism, leading to an increase in the overall prevalence of primary congenital hypothyroidism (CH) in several countries. We have performed a retrospective evaluation on the data from 251,008 (96.72%) neonates screened for thyroid-stimulating hormone (TSH) level in dried blood spot specimens taken 48 h after birth, between 2002 and 2015, using the DELFIA method. A TSH value of 15 mIU/L whole blood was used as the cutoff point until 2010 and 10 mIU/L thereafter. Primary CH was detected in 127 newborns (1/1976) of which 81.1% had permanent and 18.9% had transient CH. The prevalence of primary CH increased from 1/2489 before 2010 to 1/1585 thereafter (p = 0.131). However, the prevalence of permanent CH increased only slightly (p = 0.922), while the transient CH prevalence showed an 8-fold increase after lowering the TSH cutoff level (p < 0.001). In cases of permanent CH, we observed a lower prevalence of thyroid dysgenesis (82.7% vs. 66.7%) and a higher prevalence of a normal in situ thyroid gland (17.3% vs. 33.3%), for the period with a lower TSH cutoff value. Our findings support the impact of a lower TSH cutoff on the increasing prevalence of congenital hypothyroidism. View Full-Text
Keywords: congenital hypothyroidism; prevalence; neonatal screening; thyroid-stimulating hormone; cutoff level congenital hypothyroidism; prevalence; neonatal screening; thyroid-stimulating hormone; cutoff level
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Anastasovska, V.; Kocova, M. Impact of Lower Screening TSH Cutoff Level on the Increasing Prevalence of Congenital Hypothyroidism. Int. J. Neonatal Screen. 2017, 3, 7.

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Int. J. Neonatal Screen. EISSN 2409-515X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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